2019冠状病毒病疫苗接种状况对印度一家三级医疗中心收治的成年患者治疗结果的影响。

Effect of COVID-19 vaccination status on outcome of adult patients admitted at a tertiary care centre in India.

作者信息

Ahluwalia Bineet, Gupta Neeraj Kumar, Singh Amitabh, Ish Pranav, Dev Nishanth, Kohli Santvana, Kumar Rohit, Marwein Fellisha, Gupta Nitesh

机构信息

Department of Pulmonary and Critical Care Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi .

Department of Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi.

出版信息

Monaldi Arch Chest Dis. 2022 Apr 19;93(1). doi: 10.4081/monaldi.2022.2135.

DOI:10.4081/monaldi.2022.2135

PMID:35443571

Abstract

COVID-19 vaccination was initially started in India on 16th January 2021 after approval from national authorities. This study was carried out to assess the effect of vaccination status on the severity and clinical outcome among patients infected with COVID-19. The study included all adult COVID-19 patients admitted to our hospital from 1st April to 30th June 2021. A total of 819 patients were enrolled in the study out of which only 183 (22.3%) were vaccinated. The study documented a statistically significant reduction in the severity of illness among the vaccinated (single/double dose) (33% severe COVID-19) against the unvaccinated (43% severe COVID-19) groups; along with a reduction in mortality. On univariate and multivariate analysis, age, severity of illness and lack of COVID-19 vaccination status were associated with a statistically significant increased mortality. To conclude, this study demonstrates the role of vaccination in decreasing the severity and mortality of COVID-19 infection.

摘要

在获得国家当局批准后，印度于2021年1月16日开始首次接种新冠疫苗。本研究旨在评估疫苗接种状况对新冠病毒感染患者病情严重程度和临床结局的影响。该研究纳入了2021年4月1日至6月30日期间入住我院的所有成年新冠患者。共有819名患者参与了该研究，其中只有183名（22.3%）接种了疫苗。该研究记录了接种疫苗（单剂/双剂）组患者的病情严重程度相较于未接种疫苗组（43%为重症新冠）有统计学意义的降低（33%为重症新冠）；同时死亡率也有所降低。单因素和多因素分析显示，年龄、病情严重程度以及未接种新冠疫苗与死亡率在统计学上显著增加相关。总之，本研究证明了疫苗接种在降低新冠病毒感染严重程度和死亡率方面的作用。