[神经特异性细胞骨架蛋白]

[Neurospecific cytoskeletal proteins].

作者信息

Berezin V A, Shevchenko G M

出版信息

Ukr Biokhim Zh (1978). 1987 Jan-Feb;59(1):105-15.

Abstract

Data available in literature on neurospecific proteins of cytoskeletal structures--microtubules, microfilaments and intermediate filaments are generalized. Properties of tissue-specific cytoskeletal proteins which are typical of nerve cells are summarized. The structure, physicochemical properties, cell localization, metabolism and function of cytoskeletal proteins are characterized. The coexpression and interaction of different cytoskeletal structures are considered. An analysis of neurospecific cytoskeletal proteins is of great practical importance for neurobiology, neurooncology, neurosurgery. The proteins can be used as markers of different pathologies in the nervous system.

摘要

文献中有关细胞骨架结构的神经特异性蛋白——微管、微丝和中间丝的现有数据进行了汇总。总结了神经细胞特有的组织特异性细胞骨架蛋白的特性。对细胞骨架蛋白的结构、物理化学性质、细胞定位、代谢和功能进行了表征。考虑了不同细胞骨架结构的共表达和相互作用。对神经特异性细胞骨架蛋白的分析对神经生物学、神经肿瘤学、神经外科具有重要的实际意义。这些蛋白可作为神经系统不同病变的标志物。