Dada Tanuj, Yadav Raj Kumar, Sharma Hanjabam Barun, Netam Ritesh Kumar, Kochhar Kanwal Preet
Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
Department of Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Int J Yoga. 2022 Jan-Apr;15(1):59-69. doi: 10.4103/ijoy.ijoy_160_21. Epub 2022 Mar 21.
In healthy subjects, the intraocular pressure (IOP) is maintained by a dynamic equilibrium between continuous production of aqueous humor by ciliary bodies and continuous outflow through the two drainage pathways: trabecular meshwork and uveoscleral outflow. Here, we hypothesized that yogic ocular exercises, including extraocular muscles exercise, and modified (m), might reduce the IOP as well as stress and improve quality of life (QoL) in patients with glaucoma.
A parallel two-arm randomized controlled trial (RCT) was conducted in glaucoma patients (Control group and Intervention group). Control group patients were on standard medical treatment and intervention group patients practiced a Yoga-based lifestyle intervention (YBLI) for 4 weeks as add-on therapy with their standard medical treatment. All Participants were assessed at baseline day 1, day 14 (D14), and day 28 (D28). A minimum of 30 patients were recruited in each group.
We did not observe any statistically significant different mean IOP of right (IOP-r) or, left eyes at any time point as well as cortisol level and QoL between the two groups. However, with in intervention group, there was a reduction in IOP-r at D14 (15.54 ± 2.81 mmHg) and D28 (15.24 ± 3.1 mmHg), = 0.006 and 0.001, respectively, compared to their baseline IOP (16.26 ± 2.98).
Based on the present RCT, yoga-based ocular exercises practiced here cannot be recommended for management of raised IOP in glaucoma patients. Further larger studies are warranted with yoga-based interventions in patients with glaucoma.
CTRI/2016/03/006703.
在健康受试者中,眼内压(IOP)通过睫状体持续产生房水与通过小梁网和葡萄膜巩膜流出这两种引流途径持续流出之间的动态平衡来维持。在此,我们假设包括眼外肌运动在内的瑜伽眼部运动及其改良形式(m)可能会降低青光眼患者的眼内压以及压力,并改善生活质量(QoL)。
在青光眼患者中进行了一项平行双臂随机对照试验(RCT)(对照组和干预组)。对照组患者接受标准药物治疗,干预组患者在接受标准药物治疗的基础上,进行为期4周的基于瑜伽的生活方式干预(YBLI)作为附加治疗。所有参与者在基线第1天、第14天(D14)和第28天(D28)进行评估。每组至少招募30名患者。
我们未观察到两组在任何时间点右眼(IOP-r)或左眼的平均眼内压、皮质醇水平和生活质量有任何统计学上的显著差异。然而,在干预组中,与基线眼内压(16.26±2.98)相比,D14(15.54±2.81 mmHg)和D28(15.24±3.1 mmHg)时IOP-r有所降低,p值分别为0.006和0.001。
基于目前的RCT,此处所进行的基于瑜伽的眼部运动不能推荐用于青光眼患者高眼压的管理。有必要对青光眼患者进行进一步的基于瑜伽的干预的更大规模研究。
CTRI/2016/03/00670。