Department of Otolaryngology, Yongchuan Hospital of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 402160, China.
J Healthc Eng. 2022 Apr 11;2022:3594210. doi: 10.1155/2022/3594210. eCollection 2022.
To conduct a systematic review on the mechanism of action and use of traditional Chinese medicines (TCM) in allergic rhinitis treatment.
Allergic rhinitis (AR) is a type I allergic disease of the immune system induced by immunoglobulin E mediated inflammation and is characterized by sneezing, nasal itching, paroxysmal nasal obstruction, mucosal edema, cough, and rhinorrhea. More than 500 million people have been affected by rhinitis worldwide in the past 20 years, leading to negative effects on health, quality of life, and social relationships. Currently, the trending medicines used in the case of AR include intranasal corticosteroids and oral H1 antihistamines, which are given as combinatorial medicines supplemented with immune therapy. These medications have been found to be very effective in either the short term or long term; however, they have been found to possess some serious side effects. . The information in this article on classical and traditional Chinese medications used to treat AR was derived from original papers and reviews published in Chinese and English language journals. Two Chinese databases (Wanfang and CNKI) and three English databases (Cochrane Library, PubMed, and Embase) were utilized for data gathering.
Traditional Chinese remedies have been identified to influence the production of cytokines such as IL-5 and IL-6, which are key mediators of eosinophilic inflammation, TNF-, which stimulates TH2 cells at the site of inflammation, and NF-B, which is required for cytokine and IgE antibody production. TCM has also been shown to be successful in lowering histamine levels, preserving histological changes by decreasing the thickness of the lamina propria, and downregulating the expression of Orai1, STIM1, and TRYC1, showing low expression of Ca channel proteins.
In this review, we discussed a series of classical, traditional Chinese medications, including , , licorice root (), and others, as potential antiallergic agents and investigate their in vivo effect upon the production of cytokines and release of histamines for allergic rhinitis treatment.
系统评价中药治疗变应性鼻炎的作用机制及应用。
变应性鼻炎（AR）是一种由免疫球蛋白 E 介导的炎症引起的 I 型过敏疾病，其特征为打喷嚏、鼻痒、阵发性鼻塞、黏膜水肿、咳嗽和流涕。在过去的 20 年中，全球有超过 5 亿人受到鼻炎的影响，导致健康、生活质量和社会关系受到负面影响。目前，AR 病例中使用的流行药物包括鼻内皮质类固醇和口服 H1 抗组胺药，这些药物作为组合药物与免疫疗法一起使用。这些药物在短期或长期内都被发现非常有效；然而，它们被发现存在一些严重的副作用。本文中关于治疗 AR 的经典和传统中药的信息来自中文和英文期刊发表的原始论文和综述。我们使用了两个中文数据库（万方和中国知网）和三个英文数据库（Cochrane 图书馆、PubMed 和 Embase）来收集数据。
传统中药被认为可以影响细胞因子的产生，如白细胞介素 5 和白细胞介素 6，它们是嗜酸性粒细胞炎症的关键介质，肿瘤坏死因子-α，它刺激炎症部位的 TH2 细胞，以及核因子 kB，它是细胞因子和 IgE 抗体产生所必需的。TCM 还被证明可以成功降低组胺水平，通过减少固有层的厚度来保留组织学变化，并下调 Orai1、STIM1 和 TRYC1 的表达，显示出钙通道蛋白的低表达。
在本综述中，我们讨论了一系列经典的、传统的中药，包括辛夷、苍耳子、甘草等，作为潜在的抗过敏药物，并研究了它们对细胞因子产生和组胺释放的体内作用，用于治疗变应性鼻炎。
