Wu Ruolin, Xia Xiaotian, Hu Fan, Zhang Yajing, Wang Jingjing, He Yong, Gao Zairong
Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
Front Med (Lausanne). 2022 Apr 4;9:862690. doi: 10.3389/fmed.2022.862690. eCollection 2022.
Pulmonary epithelioid hemangioendothelioma (EHE) is a rare vascular malignancy that is typically low-to-intermediate grade. We report a 47-year-old man with a rapidly progressive pulmonary EHE who initially presented with asymptomatic pulmonary nodules. One nodule was mildly hypermetabolic on initial F-FDG PET/CT. 10 months later, the patient developed severe bone pain and night sweats. Repeat imaging revealed several lung lesions, diffuse pleural thickening, and multiple skeletal metastases with considerably increased tracer uptake. The patient underwent vertebral, pleural, and pulmonary biopsies and a diagnosis of advanced pulmonary EHE was made. His disease progressed despite four courses of antineoplastic therapy, after which he began palliative care. Pulmonary EHE can be aggressive and spread rapidly. Biopsy of hypermetabolic lung lesions using PET/CT guidance might enable early definitive diagnosis.
肺上皮样血管内皮瘤（EHE）是一种罕见的血管恶性肿瘤，通常为低级别至中级别。我们报告一名47岁男性，患有快速进展型肺EHE，最初表现为无症状性肺结节。最初的F-FDG PET/CT检查显示一个结节轻度代谢增高。10个月后，患者出现严重骨痛和盗汗。重复成像显示多个肺部病变、弥漫性胸膜增厚以及多个骨骼转移灶，示踪剂摄取显著增加。患者接受了椎体、胸膜和肺部活检，确诊为晚期肺EHE。尽管接受了四个疗程的抗肿瘤治疗，他的病情仍进展，之后开始接受姑息治疗。肺EHE可能具有侵袭性且进展迅速。使用PET/CT引导对代谢增高的肺部病变进行活检可能有助于早期明确诊断。
