State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, P. R. China.
School of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, P. R. China.
J Am Chem Soc. 2022 May 4;144(17):7610-7615. doi: 10.1021/jacs.2c02894. Epub 2022 Apr 21.
We report a new synthetic strategy of combining -carboxyanhydride (NCA) chemistry and photonic crystals for the fabrication of polypeptide structural color films. Driven by surface-initiated ring-opening polymerization, the di-NCA derivative of l-cystine (Cys) is introduced to replicate the functionalized colloidal crystal templates and construct freestanding P(Cys) films with tunable structural color. Furthermore, the feasibility of preparing patterned polypeptide photonic films is demonstrated via template microfabrication. Because of the incorporation of l-glutamate (Glu) components, the P(Cys--Glu) co-polypeptide films are endowed with a visual color responsiveness toward pH changes. Additionally, the polypeptide photonic films show on-demand degradability. Given the large family of amino acid building blocks, this powerful and versatile approach paves the way for chemical derivatization of multifunctional peptide-based optical platforms.
我们报告了一种将 - 羧基酰胺（NCA）化学和光子晶体相结合的新合成策略，用于制备多肽结构色膜。受表面引发的开环聚合的驱动，引入二-NCA 衍生物 l-胱氨酸（Cys）来复制功能化胶体晶体模板，并构建具有可调结构颜色的独立 P（Cys）膜。此外，通过模板微加工证明了制备图案化多肽光子膜的可行性。由于掺入 l-谷氨酸（Glu）成分，P（Cys-Glu）共多肽膜对 pH 值变化具有视觉颜色响应性。此外，多肽光子膜具有按需降解性。鉴于氨基酸构建块的大家族，这种强大且多功能的方法为基于多功能肽的光学平台的化学衍生化铺平了道路。
