J Pediatr Ophthalmol Strabismus. 2023 Jan-Feb;60(1):60-74. doi: 10.3928/01913913-20220228-01. Epub 2022 Apr 21.
To report wide-field fundus imaging and fluorescein angiography findings in conditions mimicking retinoblastoma (pseudoretinoblastoma).
The clinical and imaging records of 28 patients (36 eyes) imaged with RetCam 3 (Clarity Medical Systems, Inc) wide-field fundus photography and fluorescein angiography who were diagnosed as having various pseudoretinoblastoma disorders between February 2020 and August 2021 were retrospectively evaluated.
Most patients were referred with suspicion of retinoblastoma. Other patients had unresolved eye conditions and received initial treatment elsewhere and they were referred later for exclusion of retinoblastoma. On RetCam fundus photography and fluorescein angiography, pseudoretinoblastoma conditions were diagnosed as Coats disease (9 eyes), congenital glaucoma (3 eyes), persistent fetal vasculature (3 eyes), familial exudative vitreoretinopathy (2 eyes), retinopathy of prematurity (2 eyes), myelinated retinal nerve fibers (2 eyes), optic nerve hypoplasia (2 eyes), oculocutaneous albinism (2 eyes), meridional fold (2 eyes), combined hamartoma of retina and retinal pigment epithelium (2 eyes), grouped congenital hypertrophy of the retinal pigment epithelium (1 eye), retinal astrocytic hamartoma (1 eye), morning glory syndrome (1 eye), optic glioma (1 eye), giant choroidal nevus (1 eye), vasculitis (1 eye), and chorioretinitis (1 eye). RetCam imaging and fluorescein angiography demonstrated telangiectasias, microaneurysms, submacular exudation/fibrosis, capillary non-perfusion, and exudation posterior to telangiectasias in Coats disease. Hypofluorescent optic discs, peripheral non-perfusion, and vascular leakage were observed in congenital glaucoma. Large areas of capillary non-perfusion, poor foveal morphology/formation, elongated ciliary processes with hyperfluorescent central core, and hyperfluorescent fibrovascular stalk at the posterior pole were hallmarks of persistent fetal vasculature.
RetCam wide-field fundus imaging and fluorescein angiography play an important role in the diagnosis of conditions simulating retinoblastoma. .
报道模仿视网膜母细胞瘤（假性视网膜母细胞瘤）的疾病的宽视野眼底成像和荧光素血管造影结果。
回顾性分析 2020 年 2 月至 2021 年 8 月期间，使用 RetCam 3（Clarity Medical Systems，Inc.）宽视野眼底摄影和荧光素血管造影诊断为各种假性视网膜母细胞瘤疾病的 28 例患者（36 只眼）的临床和影像学记录。
大多数患者因怀疑视网膜母细胞瘤而就诊。其他患者有未解决的眼部疾病，在其他地方接受了初始治疗，后来因排除视网膜母细胞瘤而转诊。在 RetCam 眼底摄影和荧光素血管造影下，假性视网膜母细胞瘤疾病被诊断为 Coats 病（9 只眼）、先天性青光眼（3 只眼）、永存原始玻璃体血管（3 只眼）、家族性渗出性玻璃体视网膜病变（2 只眼）、早产儿视网膜病变（2 只眼）、髓鞘化视网膜神经纤维（2 只眼）、视神经发育不良（2 只眼）、眼皮肤白化病（2 只眼）、子午线褶皱（2 只眼）、视网膜和视网膜色素上皮联合错构瘤（2 只眼）、视网膜色素上皮先天性肥大组（1 只眼）、视网膜星形细胞瘤（1 只眼）、牵牛花综合征（1 只眼）、视神经胶质瘤（1 只眼）、脉络膜巨大神经纤维瘤（1 只眼）、血管炎（1 只眼）和脉络膜炎（1 只眼）。RetCam 成像和荧光素血管造影显示 Coats 病存在毛细血管扩张、微动脉瘤、黄斑下渗出/纤维化、毛细血管无灌注和毛细血管扩张后渗出。先天性青光眼观察到弱荧光视盘、周边无灌注和血管渗漏。永存原始玻璃体血管的特征是大片毛细血管无灌注、黄斑形态/形成不良、睫状突延长伴中央核心强荧光和后极部强荧光纤维血管蒂。
RetCam 宽视野眼底成像和荧光素血管造影在诊断模仿视网膜母细胞瘤的疾病中具有重要作用。
