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A Rationale for the Use of Norepinephrine after the Control of Bleeding in Hemorrhagic Shock?

作者信息

Asfar Pierre, May Clive

机构信息

Centre Hospitalo-Universitaire d'Angers Université d'Angers Angers, France.

Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville, Victoria, Australia.

出版信息

Am J Respir Crit Care Med. 2022 Jul 1;206(1):1-2. doi: 10.1164/rccm.202203-0521ED.

DOI:10.1164/rccm.202203-0521ED
PMID:35446239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9954333/
Abstract
摘要

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A small dose of arginine vasopressin in combination with norepinephrine is a good early treatment for uncontrolled hemorrhagic shock after hemostasis.止血后未控制的出血性休克早期,小剂量血管加压素联合去甲肾上腺素治疗效果良好。
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Low-dose norepinephrine in combination with hypotensive resuscitation may prolong the golden window for uncontrolled hemorrhagic shock in rats.低剂量去甲肾上腺素联合低血压复苏可能会延长大鼠非控制性出血性休克的黄金救治时间窗。
Front Physiol. 2022 Sep 19;13:1004714. doi: 10.3389/fphys.2022.1004714. eCollection 2022.

本文引用的文献

1
Renal Microcirculation and Function in a Pig Model of Hemorrhagic Shock Resuscitation with Norepinephrine.去甲肾上腺素复苏失血性休克猪模型的肾微循环和功能
Am J Respir Crit Care Med. 2022 Jul 1;206(1):34-43. doi: 10.1164/rccm.202109-2120OC.
2
Kidney Microcirculation as a Target for Innovative Therapies in AKI.肾脏微循环作为急性肾损伤创新疗法的靶点
J Clin Med. 2021 Sep 7;10(18):4041. doi: 10.3390/jcm10184041.
3
The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats.靶向Tie2对大鼠失血性休克诱导的肾灌注紊乱的影响。
Intensive Care Med Exp. 2021 May 17;9(1):23. doi: 10.1186/s40635-021-00389-5.
4
Vasopressors in Trauma: A Never Event?创伤性升压药:永不发生的事件?
Anesth Analg. 2021 Jul 1;133(1):68-79. doi: 10.1213/ANE.0000000000005552.
5
Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial.低剂量精氨酸加压素对创伤性出血性休克患者输血需求的影响:一项随机临床试验。
JAMA Surg. 2019 Nov 1;154(11):994-1003. doi: 10.1001/jamasurg.2019.2884.
6
The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.欧洲创伤后大出血及凝血功能障碍管理指南:第五版。
Crit Care. 2019 Mar 27;23(1):98. doi: 10.1186/s13054-019-2347-3.
7
Hemorrhagic Shock.失血性休克
N Engl J Med. 2018 Jan 25;378(4):370-379. doi: 10.1056/NEJMra1705649.
8
Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma.严重创伤性出血患者的损伤控制复苏:来自东部创伤外科学会的实践管理指南
J Trauma Acute Care Surg. 2017 Mar;82(3):605-617. doi: 10.1097/TA.0000000000001333.
9
Intrarenal and urinary oxygenation during norepinephrine resuscitation in ovine septic acute kidney injury.在绵羊脓毒症急性肾损伤的去甲肾上腺素复苏期间肾内和尿氧合作用。
Kidney Int. 2016 Jul;90(1):100-8. doi: 10.1016/j.kint.2016.02.017. Epub 2016 Apr 16.
10
Norepinephrine Decreases Fluid Requirements and Blood Loss While Preserving Intestinal Villi Microcirculation during Fluid Resuscitation of Uncontrolled Hemorrhagic Shock in Mice.去甲肾上腺素在小鼠失血性休克液体复苏期间减少液体需求量和失血量,同时维持肠绒毛微循环。
Anesthesiology. 2015 May;122(5):1093-102. doi: 10.1097/ALN.0000000000000639.