Hu Keming, Yang Zeyuan, Zhao Yanlong, Wang Yuguang, Luo Jing, Tuo Biyang, Zhang Hongyu
College of Mining, Guizhou University, Guiyang 550025, China.
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Langmuir. 2022 May 10;38(18):5924-5933. doi: 10.1021/acs.langmuir.2c00600. Epub 2022 Apr 21.
In orthopedics, developing functionalized biomaterials to enhance osteogenesis and bacterial resistance is crucial. Although poly(ether ether ketone) (PEEK) is regarded as an important engineering plastic for biomedical material with excellent mechanical properties and biocompatibility, its biological inertness has greatly compromised its application in biomedical engineering. Inspired by the catecholamine chemistry of mussels, we propose a universal and versatile approach for enhancing the osteogenesis and antibacterial performances of PEEK based on surface functionalization of polydopamine-modified nanohydroxyapatite and lysozyme simultaneously. The characterizations of surface morphology and elemental composition revealed that the composite coating was successfully added to the PEEK surface. Additionally, the cell experiment and biomineralization assay indicated that the composite coating-modified PEEK was biocompatible with significantly improved bioactivity to promote osteogenesis and biomineralization compared with the untreated PEEK. Furthermore, the antibacterial test demonstrated that the composite coating had a strongly destructive effect on two bacteria ( and ) with antibacterial ratios of 98.7% and 96.1%, respectively. In summary, the bioinspired method for surface functionalization can enhance the osteogenesis and bacterial resistance of biomedical materials, which may represent a potential approach for designing functionalized implants in orthopedics.
在骨科领域，开发功能化生物材料以增强骨生成和抗菌性能至关重要。尽管聚醚醚酮（PEEK）被视为一种重要的生物医学材料工程塑料，具有优异的机械性能和生物相容性，但其生物惰性极大地限制了其在生物医学工程中的应用。受贻贝儿茶酚胺化学的启发，我们提出了一种通用且多功能的方法，通过聚多巴胺修饰的纳米羟基磷灰石和溶菌酶的表面功能化同时增强PEEK的骨生成和抗菌性能。表面形态和元素组成的表征表明复合涂层成功添加到了PEEK表面。此外，细胞实验和生物矿化测定表明，与未处理的PEEK相比，复合涂层修饰的PEEK具有生物相容性，其生物活性显著提高，可促进骨生成和生物矿化。此外，抗菌测试表明复合涂层对两种细菌（ 和 ）具有强烈的破坏作用，抗菌率分别为98.7%和96.1%。总之，这种受生物启发的表面功能化方法可以增强生物医学材料的骨生成和抗菌性能，这可能代表了一种在骨科领域设计功能化植入物的潜在方法。
