Huizhou Central People's Hospital.
Chinese University of Hong Kong.
Oncol Nurs Forum. 2022 May 1;49(3):243-254. doi: 10.1188/22.ONF.243-254.
To assess the symptom cluster of fatigue, sleep disturbance, and depression among female patients with breast cancer receiving chemotherapy, and to evaluate its impact on quality of life (QOL) and symptom severity.
SAMPLE & SETTING: 372 patients receiving adjuvant chemotherapy recruited from two tertiary hospitals in China.
METHODS & VARIABLES: Symptom severity and QOL were evaluated using the Brief Fatigue Inventory, Pittsburgh Sleep Quality Index, Patient Health Questionnaire-9, and Functional Assessment of Cancer Therapy-Breast on the eighth day after receiving chemotherapy.
All symptoms positively correlated with each other. Although the symptom cluster was significantly associated with decreased QOL, individualized symptom severity worsened as the number of symptoms increased.
The prevalence of and interactions among fatigue, sleep disturbance, and depression negatively affect symptom severity and patients' QOL. Conducting early assessment followed by effective cluster-based interventions is needed to manage this symptom cluster.
评估接受化疗的女性乳腺癌患者疲劳、睡眠障碍和抑郁的症状群，并评估其对生活质量（QOL）和症状严重程度的影响。
从中国两家三级医院招募了 372 名接受辅助化疗的患者。
在接受化疗后的第八天，使用简要疲劳量表、匹兹堡睡眠质量指数、患者健康问卷-9 和癌症治疗功能评估-乳房评估症状严重程度和 QOL。
所有症状均呈正相关。尽管症状群与 QOL 下降显著相关，但随着症状数量的增加，个体症状严重程度也会恶化。
疲劳、睡眠障碍和抑郁的发生率和相互作用对症状严重程度和患者的 QOL 产生负面影响。需要进行早期评估，然后进行基于集群的有效干预，以管理这种症状群。
