Wong Wai Man, Chan Dorothy N S, Choi Kai Chow, Choy Yin Ping, So Winnie K W
The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong SAR, China.
Princess Margaret Hospital, Hospital Authority, Hong Kong SAR, China.
Asia Pac J Oncol Nurs. 2023 Jul 3;10(8):100269. doi: 10.1016/j.apjon.2023.100269. eCollection 2023 Aug.
To examine the feasibility and acceptability of a multi-modal intervention for managing the cancer-related fatigue-sleep disturbance-depressed mood (F-S-D) symptom cluster in patients with breast cancer (BC) and receiving chemotherapy in Hong Kong, and the preliminary effects of such intervention on the occurrence of the F-S-D symptom cluster in these patients.
This study was a single-blind randomized controlled trial. Patients with BC scheduled for chemotherapy were recruited. Intervention participants received a weekly nurse-led multi-modal intervention lasting 7 weeks. The feasibility parameters and adverse events were assessed using logbook records. Acceptability was evaluated using a program evaluation questionnaire. F-S-D symptoms and quality of life (QOL) were measured at baseline (T0), upon intervention completion (T1), and 3 months after intervention completion (T2). Generalized estimating equation analyses were used.
Fifty participants were enrolled. The eligibility and enrollment rates were 11% and 87.7%, respectively. The rate of adherence to the intervention was 96%. No adverse events were reported. All participants were satisfied with the intervention, which had significant effects in terms of reducing the occurrence of the F-S-D symptom cluster at T2 ( = 0.035) and improving QOL at T1 and T2 (T1: = 0.035; T2: = 0.012).
The multi-modal intervention is a feasible, acceptable, and safe intervention that demonstrated preliminary positive effects in managing the F-S-D symptom cluster and improving QOL in patients with BC and receiving chemotherapy in Hong Kong. This study provides key insights into F-S-D symptom cluster management in patients with BC.
ChiCTR2100047819 (Chinese Clinical Trial Register).
探讨多模式干预措施用于管理香港乳腺癌（BC）化疗患者癌症相关疲劳-睡眠障碍-抑郁情绪（F-S-D）症状群的可行性和可接受性，以及该干预措施对这些患者F-S-D症状群发生情况的初步影响。
本研究为单盲随机对照试验。招募计划接受化疗的BC患者。干预组参与者接受为期7周、由护士主导的每周一次的多模式干预。使用日志记录评估可行性参数和不良事件。使用项目评估问卷评估可接受性。在基线（T0）、干预结束时（T1）和干预结束后3个月（T2）测量F-S-D症状和生活质量（QOL）。采用广义估计方程分析。
共纳入50名参与者。合格率和入组率分别为11%和87.7%。干预依从率为96%。未报告不良事件。所有参与者对干预均满意，该干预在T2时对减少F-S-D症状群的发生有显著效果（P = 0.035），并在T1和T2时改善了生活质量（T1：P = 0.035；T2：P = 0.012）。
多模式干预是一种可行、可接受且安全的干预措施，在管理香港BC化疗患者的F-S-D症状群和改善生活质量方面显示出初步积极效果。本研究为BC患者F-S-D症状群管理提供了关键见解。
ChiCTR2100047819（中国临床试验注册中心）
