Lehtola J, Karvonen A L, Tunturi-Hihnala H
Ann Clin Res. 1978 Feb;10(1):19-23.
The effect of carbenoxolone on the healing of gastric ulcer and erosions was compared with that of placebo. The series consisted of 20 patients with chronic gastric ulcers and 20 patients with superficial erosions of the stomach. The diagnosis as well as the follow-up of the lesions were based on gastroscopic examinations. The ulcers were measured gastroscopically. A double-blind method was used. Besides carbenoxolone 50 mg or placebo three times daily, all the patients received antacids in fixed dosage for six weeks. Subjective symptoms and cardiovascular side-effects were recorded. Maximal acid output and serum gastrin levels were measured before and after the treatment. No difference was seen between carbenoxolone and placebo groups with regard to the healing rate of the ulcers of disappearance of the erosions. The subjective symptoms subsided significantly faster in the treatment groups than in the control groups. No cardiovascular side-effects were evident during the treatment with carbenoxolone. One patient needed potassium supplements. Carbenoxolone had no effect on the pentagastrin-stimulated gastric acid secretion nor on the serum gastrin values.
将甘珀酸对胃溃疡和糜烂愈合的作用与安慰剂进行了比较。该研究系列包括20例慢性胃溃疡患者和20例胃浅表糜烂患者。病变的诊断及随访均基于胃镜检查。通过胃镜测量溃疡。采用双盲法。除了每日三次服用50毫克甘珀酸或安慰剂外，所有患者均接受固定剂量的抗酸剂治疗六周。记录主观症状和心血管副作用。在治疗前后测量最大胃酸分泌量和血清胃泌素水平。在溃疡愈合率或糜烂消失方面，甘珀酸组和安慰剂组之间未见差异。治疗组的主观症状消退明显快于对照组。在使用甘珀酸治疗期间，未发现明显的心血管副作用。有1例患者需要补充钾。甘珀酸对五肽胃泌素刺激的胃酸分泌及血清胃泌素值均无影响。
