Brailski Kh, Dimitrov B
Vutr Boles. 1979;18(5):37-44.
The results are reported from the treatment of 30 patients with gastric and 13 with diodenal ulcers with biogastrone in the course of 20 days (300 mg were given the first week, where on -- 150 mg daily). A more favourable effect upon the clinical symptoms and ulcer were observed in the patients with gastric ulcer (the symptoms disappeared in 87 per cent whereas the ulcer -- in 32 per cent) as compared with the duodenal ulcer (the symptoms disappeared in 46 per cent, whereas -- the ulcer in none). Biogastrone treatment influences the pain in a higher per cent as compared with Caved-S and oxyferroscorbon (p greater then 0.05), whereas regards the rest of the clinical symptoms -- no statistically significant difference was established. As compared with the treatment with oxyferroscorbon, Caved-A and cimetidin, biogastrone has a slower effect on the subjective complaints and the ulcer niche. After biogastrone treatment, the indices of gastric secretion and acidity decrease and the sialic acid in gastric juice is increased only in the gastric ulcer, but does not change considerably in the duodenal ulcer. The rest of the laboratory indices do not change with biogastrone treatment. In two of the patients, in the course of biogastrone treatment, light edema appeared on the face and the arterial blood pressure was elevated in other two, disappearing after the treatment without any additional treatment. Biogastrone treatment is indicated mainly in cases with gastric ulcer, with decreased sialic acid in gastric juice.
报告了用胃泌素治疗30例胃溃疡患者和13例十二指肠溃疡患者20天的结果（第一周给予300毫克，此后每天150毫克）。与十二指肠溃疡患者相比，胃溃疡患者的临床症状和溃疡得到了更有利的改善（87%的患者症状消失，32%的患者溃疡愈合），而十二指肠溃疡患者症状消失的比例为46%，溃疡无愈合者。与维U颠茄铝胶囊和富马酸亚铁相比，胃泌素治疗对疼痛的缓解率更高（p>0.05），而在其他临床症状方面，未发现统计学上的显著差异。与富马酸亚铁、维U颠茄铝胶囊和西咪替丁治疗相比，胃泌素对主观症状和溃疡龛的作用较慢。胃泌素治疗后，胃溃疡患者的胃分泌和酸度指标下降，胃液中的唾液酸仅在胃溃疡患者中增加，而在十二指肠溃疡患者中变化不大。其他实验室指标在胃泌素治疗后无变化。在两名患者中，胃泌素治疗过程中出现面部轻度水肿，另外两名患者动脉血压升高，治疗后未经任何额外治疗即消失。胃泌素治疗主要适用于胃溃疡且胃液中唾液酸降低的病例。
