RIKEN Center for Brain Science, RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research, Japan.
Curr Opin Neurobiol. 2022 Jun;74:102541. doi: 10.1016/j.conb.2022.102541. Epub 2022 Apr 18.
Thermotaxis behavior of Caenorhabditis elegans is robust and highly plastic. A pair of sensory neurons, AFD, memorize environmental/cultivation temperature and communicate with a downstream neural circuit to adjust the temperature preference of the animal. This results in a behavioral bias where worms will move toward their cultivation temperature on a thermal gradient. Thermotaxis of C. elegans is also affected by the internal state and is temporarily abolished when worms are starved. Here I will discuss how C. elegans is able to modulate its behavior based on temperature by integrating environmental and internal information. Recent studies show that some parasitic nematodes have a similar thermosensory mechanism to C. elegans and exhibit cultivation-temperature-dependent thermotaxis. I will also discuss the common neural mechanisms that regulate thermosensation and thermotaxis in C. elegans and Strongyloides stercoralis.
秀丽隐杆线虫的趋温行为稳健且具有高度可塑性。一对感觉神经元 AFD 可记忆环境/培养温度，并与下游神经回路进行通讯，从而调节动物对温度的偏好。这导致了一种行为偏差，即线虫会在热梯度上向其培养温度移动。线虫的趋温性也受到内部状态的影响，当线虫饥饿时，趋温性会暂时消失。在这里，我将讨论秀丽隐杆线虫如何通过整合环境和内部信息来调节其基于温度的行为。最近的研究表明，一些寄生线虫具有类似于秀丽隐杆线虫的热感觉机制，并表现出与培养温度相关的趋温性。我还将讨论调节秀丽隐杆线虫和粪类圆线虫的热感觉和趋温性的共同神经机制。
