Lahdensuo A
Ann Clin Res. 1978 Apr;10(2):75-8.
The efficacy of 265 mg theophylline (150 mg of the theophylline being slow-release) and the combination of 265 mg theophylline + 7.5 mg hydroxyzine hydrochloride were compared in a double-blind cross-over placebo-controlled study in 12 patients with chronic reversible bronchial asthma. The patients took their drugs at 7.00 a.m., 1.00 p.m. and 7.00 p.m. During the trial the patients measured their peak expiratory flow (PEF) every day at 7.00 a.m., 10.00 a.m. and 9.30 p.m. The frequency and severity of symptoms and side-effects as well as the auxiliary use of isoprenaline inhalations were also recorded. The trial involved three three-day periods. Both oral theophylline and the combination of theophylline + hydroxyzine caused significant improvements in PEF in all measurement times. The PEF-level was higher when the combination was used than with plain theophylline, though the difference was not significant. Only the combination of theophylline + hydroxyzine had a significant effect on the symptoms, and the use of additional isoprenaline inhalations was also reduced during the combination period. Side-effects were minimal. Circadian variation of bronchial obstruction was seen in all these patients.
在一项针对12例慢性可逆性支气管哮喘患者的双盲交叉安慰剂对照研究中，对265毫克茶碱（其中150毫克为缓释茶碱）以及265毫克茶碱与7.5毫克盐酸羟嗪的组合进行了疗效比较。患者于上午7点、下午1点和晚上7点服药。在试验期间，患者每天上午7点、上午10点和晚上9点30分测量其呼气峰值流速（PEF）。还记录了症状和副作用的频率及严重程度，以及异丙肾上腺素吸入剂的辅助使用情况。该试验包括三个为期三天的阶段。口服茶碱以及茶碱与羟嗪的组合在所有测量时间均使PEF有显著改善。使用组合药物时的PEF水平高于单纯使用茶碱时，不过差异并不显著。只有茶碱与羟嗪的组合对症状有显著影响，且在使用组合药物期间，异丙肾上腺素吸入剂的额外使用也有所减少。副作用极小。所有这些患者均出现支气管阻塞的昼夜变化。
