Wong Karianne Sretavan, Chou Tina, Peters Amy T, Ellard Kristen K, Nierenberg Andrew A, Dougherty Darin D, Deckersbach Thilo
Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA; Dauten Family Center for Bipolar Treatment Innovation, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
J Psychiatr Res. 2022 Jun;150:317-323. doi: 10.1016/j.jpsychires.2022.03.053. Epub 2022 Apr 8.
The Frontal Systems Behavior Scale (FrSBe) is a self-report measure that assesses difficulties with cognitive and emotional control such as apathetic behavior, lack of inhibitory control, and executive dysfunction. Previous neuroimaging studies highlight the involvement of the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and dorsolateral prefrontal cortex (DLPFC) in these processes. In this study, we investigated whether there was convergence across subjective and objective measures of apathy, disinhibition, and executive dysfunction. Specifically, we studied whether ACC, OFC, and DLPFC activation during a modified version of the Multi-Source Interference Task (MSIT), is associated with FrSBe apathy, disinhibition, and executive dysfunction scores, in healthy controls (HC) and individuals with Bipolar Disorder (BD), who commonly exhibit difficulties in these domains. Individuals with BD (n = 31) and HCs (n = 31) with no current or past psychiatric illness completed the FrSBe and the MSIT during fMRI scanning. We investigated task-specific changes in the ACC, DLPFC, and OFC and their correlations with FrSBe apathy, disinhibition, and executive dysfunction subscale scores, respectively. Individuals with BD and the HC group demonstrated greater ACC, DLPFC, and OFC activation during MSIT interference conditions compared with non-interference conditions. Furthermore, there was a significant negative correlation between OFC activation and disinhibition scores, which remained significant after accounting for medication load. Together, these results demonstrate the FrSBe disinhibition subscale, in particular, can be a self-report measure that converges with behavioral and neural markers of disinhibition in BD.
额叶系统行为量表（FrSBe）是一种自我报告测量工具，用于评估认知和情绪控制方面的困难，如冷漠行为、抑制控制缺失和执行功能障碍。先前的神经影像学研究强调了前扣带回皮质（ACC）、眶额皮质（OFC）和背外侧前额叶皮质（DLPFC）在这些过程中的参与。在本研究中，我们调查了冷漠、去抑制和执行功能障碍的主观和客观测量之间是否存在一致性。具体而言，我们研究了在多源干扰任务（MSIT）的修改版本中，ACC、OFC和DLPFC的激活是否与FrSBe冷漠、去抑制和执行功能障碍得分相关，研究对象为健康对照者（HC）和双相情感障碍（BD）患者，他们在这些领域通常存在困难。没有当前或既往精神疾病的BD患者（n = 31）和HC（n = 31）在功能磁共振成像扫描期间完成了FrSBe和MSIT。我们分别研究了ACC、DLPFC和OFC的任务特异性变化及其与FrSBe冷漠、去抑制和执行功能障碍子量表得分的相关性。与非干扰条件相比，BD患者和HC组在MSIT干扰条件下ACC、DLPFC和OFC的激活更强。此外，OFC激活与去抑制得分之间存在显著负相关，在考虑药物负荷后仍具有显著性。总之，这些结果表明，特别是FrSBe去抑制子量表可以作为一种自我报告测量工具，与BD患者去抑制的行为和神经标志物具有一致性。
