Chiaravalloti Nancy D, DeLuca John
Kessler Medical Rehabilitation Research and Education Corporation, West Orange, New Jersey 07052, USA.
Cogn Behav Neurol. 2003 Mar;16(1):54-67. doi: 10.1097/00146965-200303000-00007.
The current study examines the utility of the Frontal Systems Behavior Scale (FrSBe) to document behavioral changes in people with multiple sclerosis (MS).
MS results in widespread central nervous system lesions that have a propensity for affecting frontal and parietal brain regions. As a result, behavioral symptoms may present, including disorders of executive functioning, apathy, and disinhibition.
Twenty-six people with MS and 15 healthy controls (HC) underwent neuropsychological testing and completed the Frontal Systems Behavior Scale (FrSBe), and measures of emotional functioning.
Behavioral ratings for the MS group prior to illness were equivalent to those of the HC group. After illness however, a clinically and statistically significant increase was noted on two of three FrSBe scales, the apathy scale and the executive dysfunction scale. Relationships were also noted between the FrSBe family and self-report forms after illness and measures of neuropsychological performance, particularly information processing, working memory, and executive control. In contrast, physical disease progression was correlated with family ratings of behavior, but not self-ratings.
The FrSBe appears to be a sensitive measure of behavioral change in people with MS. Self-ratings and family ratings of behavioral changes are related to measures of neuropsychological performance. However, physical symptoms of MS are related only to the family ratings of behavior.
本研究探讨额叶系统行为量表（FrSBe）在记录多发性硬化症（MS）患者行为变化方面的效用。
MS会导致广泛的中枢神经系统病变，这些病变容易影响额叶和顶叶脑区。因此，可能会出现行为症状，包括执行功能障碍、冷漠和去抑制。
26名MS患者和15名健康对照者（HC）接受了神经心理学测试，并完成了额叶系统行为量表（FrSBe）以及情绪功能测量。
MS组患病前的行为评分与HC组相当。然而，患病后，FrSBe三个量表中的两个，即冷漠量表和执行功能障碍量表，在临床和统计学上有显著增加。患病后FrSBe家庭版和自评版与神经心理学表现的测量之间也存在关联，特别是信息处理、工作记忆和执行控制方面。相比之下，身体疾病进展与行为的家庭评分相关，但与自评无关。
FrSBe似乎是MS患者行为变化的敏感测量指标。行为变化的自评和家庭评分与神经心理学表现的测量相关。然而，MS的身体症状仅与行为的家庭评分相关。
