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社区获得性脑膜炎的潜在威胁——来自印度旁遮普邦的罕见病例报告

A Lurking Threat of Community-Acquired Meningitis-A Rare Case Report from Punjab, India.

作者信息

Jindal Navodhya, Jain Sonia, Bhowmick Arghya, Bhargava Vyom

机构信息

Harvard Medical Centre, Moga 142001, Punjab, India.

Department of Paramedical Science, Lala Lajpat Rai College of Pharmacy, Moga 142001, Punjab, India.

出版信息

Medicines (Basel). 2022 Mar 31;9(4):27. doi: 10.3390/medicines9040027.

DOI:10.3390/medicines9040027
PMID:35447875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9025329/
Abstract

Background: Acinetobacter spp. are a potential life-threatening cause of severe meningitis noted as a nosocomial infection after neurosurgical procedures in patients admitted to neurosurgical ICUs. Community-acquired Acinetobacter meningitis is extremely rare, and only a few cases have been reported in the literature. Case presentation: In this study, we report a patient from Punjab, India, who was infected after a roadside accident in which he developed CSF otorrhea and subsequent meningitis with Acinetobacter lwoffii. The patient was managed with the cephalosporin group of antibiotics as per the sensitivity report. For the first time, we report a rare case report of community-acquired Acinetobacter meningitis from Punjab, India. Conclusions: This case report highlights the potential pathogenicity of Acinetobacter lwoffii and increases concerns that this organism might rapidly evolve into a dreadful antibiotic-resistant community pathogen.

摘要

背景

不动杆菌属是严重脑膜炎的一个潜在的危及生命的病因,在入住神经外科重症监护病房的患者中,它被视为神经外科手术后的医院感染。社区获得性不动杆菌脑膜炎极为罕见,文献中仅报道了少数病例。病例报告:在本研究中,我们报告了一名来自印度旁遮普邦的患者,他在一次路边事故后感染,事故中他出现了脑脊液耳漏,随后感染了洛菲不动杆菌并引发脑膜炎。根据药敏报告,该患者使用头孢菌素类抗生素进行治疗。我们首次报告了一例来自印度旁遮普邦的社区获得性不动杆菌脑膜炎的罕见病例报告。结论:本病例报告突出了洛菲不动杆菌的潜在致病性,并增加了人们对该病原体可能迅速演变成一种可怕的耐抗生素社区病原体的担忧。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50cc/9025329/f2b1e1290174/medicines-09-00027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50cc/9025329/abad35c000e6/medicines-09-00027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50cc/9025329/6d9c85a1441c/medicines-09-00027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50cc/9025329/f2b1e1290174/medicines-09-00027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50cc/9025329/abad35c000e6/medicines-09-00027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50cc/9025329/6d9c85a1441c/medicines-09-00027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50cc/9025329/f2b1e1290174/medicines-09-00027-g003.jpg

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本文引用的文献

1
Carbapenemases: Transforming into a Yet More Dangerous Menace.碳青霉烯酶:将 转变为更危险的威胁。
Biomolecules. 2020 May 6;10(5):720. doi: 10.3390/biom10050720.
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Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review.抗菌药物耐药时代对抗ESKAPE病原体的新兴策略:综述
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ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.欧洲临床微生物学与感染病学会指南:急性细菌性脑膜炎的诊断与治疗
Clin Microbiol Infect. 2016 May;22 Suppl 3:S37-62. doi: 10.1016/j.cmi.2016.01.007. Epub 2016 Apr 7.
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Use of 16S rRNA gene for identification of a broad range of clinically relevant bacterial pathogens.使用16S rRNA基因鉴定多种临床相关细菌病原体。
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5
Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections.药物穿透血脑屏障/血脑脊液屏障以治疗中枢神经系统感染。
Clin Microbiol Rev. 2010 Oct;23(4):858-83. doi: 10.1128/CMR.00007-10.
6
A case of community-acquired Acinetobacter baumannii meningitis - has the threat moved beyond the hospital?一例社区获得性鲍曼不动杆菌脑膜炎——威胁已超出医院范围了吗?
J Med Microbiol. 2008 May;57(Pt 5):676-678. doi: 10.1099/jmm.0.47781-0.
7
Community-acquired Acinetobacter infections.社区获得性不动杆菌感染
Eur J Clin Microbiol Infect Dis. 2007 Dec;26(12):857-68. doi: 10.1007/s10096-007-0365-6.
8
Fulminant community-acquired Acinetobacter baumannii pneumonia as a distinct clinical syndrome.暴发性社区获得性鲍曼不动杆菌肺炎作为一种独特的临床综合征。
Chest. 2006 Jan;129(1):102-9. doi: 10.1378/chest.129.1.102.
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Community-acquired bacterial meningitis in adults: the epidemiology, timing of appropriate antimicrobial therapy, and prognostic factors.成人社区获得性细菌性脑膜炎:流行病学、适当抗菌治疗时机及预后因素
Clin Neurol Neurosurg. 2002 Sep;104(4):352-8. doi: 10.1016/s0303-8467(02)00052-5.
10
Community-acquired Acinetobacter meningitis in adults.成人社区获得性不动杆菌脑膜炎
Infection. 2000 Nov-Dec;28(6):395-7. doi: 10.1007/s150100070013.