Karmelić Ivana, Salarić Ivan, Baždarić Ksenija, Rožman Marko, Zajc Ivan, Mravak-Stipetić Marinka, Bago Ivona, Brajdić Davor, Lovrić Jasna, Macan Darko
Department of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Department of Oral Surgery, University of Zagreb School of Dental Medicine, Av. Gojka Šuška 6, 10000 Zagreb, Croatia.
Dent J (Basel). 2022 Apr 15;10(4):70. doi: 10.3390/dj10040070.
Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimulated (SWS) saliva was sampled from 29 patients with T1N0M0 OSCC and 29 sex- and age-matched healthy individuals. Statistical difference was observed in SCCA1 and SCCA2 levels both in UWS and SWS samples. TROP2 was not measurable in most of the salivary samples. Both SCCA1 and SCCA2 could represent potential biomarkers for the early-stage OSCC. Research on a larger sample and biomarker validation is needed to assess the clinical potential of SCCA1 and SCCA2 in the OSCC early diagnostics.
口腔鳞状细胞癌（OSCC）常被诊断为晚期。本文旨在确定T1N0M0期OSCC患者唾液中鳞状细胞癌抗原1（SCCA1）、鳞状细胞癌抗原2（SCCA2）和滋养层细胞表面抗原2（TROP2）的值，并将其与健康个体的值进行比较。从29例T1N0M0期OSCC患者和29例年龄和性别匹配的健康个体中采集非刺激性（UWS）和刺激性（SWS）唾液。在UWS和SWS样本中，SCCA1和SCCA2水平均观察到统计学差异。大多数唾液样本中无法检测到TROP2。SCCA1和SCCA2都可能是早期OSCC的潜在生物标志物。需要对更大样本进行研究并验证生物标志物，以评估SCCA1和SCCA2在OSCC早期诊断中的临床潜力。
