Chávez-Gutiérrez Edwin, Fuentes-Venado Claudia Erika, Rodríguez-Páez Lorena, Guerra-Araiza Christian, Larqué Carlos, Martínez-Herrera Erick, Ocharan-Hernández María Esther, Lomelí Joel, Loza-Mejía Marco A, Salazar Juan Rodrigo, Meneses-Ruiz Dulce María, Gallardo Juan Manuel, Pinto-Almazán Rodolfo
Doctorado en Ciencias en Biomedicina y Biotecnología Molecular, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Servicio de Medicina Física y Rehabilitación, Hospital General de Zona No 197, Texcoco 56108, Mexico.
Metabolites. 2022 Apr 12;12(4):341. doi: 10.3390/metabo12040341.
Metabolic syndrome (MetS) contributes to the spread of cardiovascular diseases, diabetes mellitus type 2, and neurodegenerative diseases. Evaluation of sex- and hormone-dependent changes in body weight, blood pressure, blood lipids, oxidative stress markers, and alterations in different types of memory in Sprague-Dawley rats fed with a high fat and high fructose (HFHF) diet were evaluated. After 12 weeks of feeding the male and female rats with HFHF, body weight gain, increase in blood pressure, and generation of dyslipidemia compared to the animals fed with chow diet were observed. Regarding memory, it was noted that gonadectomy reverted the effects of HFHF in the 24 h novel object recognition task and in spatial learning/memory analyzed through Morris water maze, males being more affected than females. Nevertheless, gonadectomy did not revert long-term memory impairment in the passive avoidance task induced by HFHF nor in male or female rats. On the other hand, sex-hormone-diet interaction was observed in the plasma concentration of malondialdehyde and nitric oxide. These results suggest that the changes observed in the memory and learning of MetS animals are sex- and hormone-dependent and correlate to an increase in oxidative stress.
代谢综合征（MetS）会促使心血管疾病、2型糖尿病和神经退行性疾病的传播。我们评估了用高脂肪高果糖（HFHF）饮食喂养的Sprague-Dawley大鼠体重、血压、血脂、氧化应激标志物的性别和激素依赖性变化，以及不同类型记忆的改变。在用HFHF喂养雄性和雌性大鼠12周后，与喂食普通饲料的动物相比，观察到体重增加、血压升高和血脂异常。关于记忆，我们注意到去势逆转了HFHF在24小时新物体识别任务以及通过莫里斯水迷宫分析的空间学习/记忆方面的影响，雄性比雌性受影响更大。然而，去势并未逆转HFHF诱导的被动回避任务中的长期记忆损伤，无论是雄性还是雌性大鼠。另一方面，在丙二醛和一氧化氮的血浆浓度中观察到了性激素-饮食相互作用。这些结果表明，在MetS动物的记忆和学习中观察到的变化是性别和激素依赖性的，并且与氧化应激的增加相关。
