Department of Radiology, Jeonbuk National University Medical School, Jeonju 54896, Korea.
Research Institute of Clinical Medicine, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Institute of Medical Science, Jeonju 54970, Korea.
Tomography. 2022 Apr 3;8(2):1024-1032. doi: 10.3390/tomography8020082.
Purpose: The aim of this study was to evaluate the role of Pi10 in patients with fibrotic interstitial lung abnormality (fibrotic ILA) in a chest CT, according to cumulative cigarette smoking. Methods: We retrospectively assessed 54 fibrotic ILA patients and 18 healthy non-smokers (control) who underwent non-enhanced CT and pulmonary function tests. We quantitatively analyzed airway changes (the inner luminal area, airway inner parameter, airway wall thickness, Pi10, skewness, and kurtosis) in the chest CT of fibrotic ILA patients, and the fibrotic ILA patients were categorized into groups based on pack-years: light, moderate, heavy. Airway change data and pulmonary function tests among the three groups of fibrotic ILA patients were compared with those of the control group by one-way ANOVA. Results: Mean skewness (2.58 ± 0.36) and kurtosis (7.64 ± 2.36) in the control group were significantly different from those of the fibrotic ILA patients (1.89 ± 0.37 and 3.62 ± 1.70, respectively, p < 0.001). In fibrotic ILA group, only heavy smokers had significantly increased Pi10 (mean increase 0.04, p = 0.013), increased airway wall thickness of the segmental bronchi (mean increase 0.06 mm, p = 0.005), and decreased lung diffusing capacity for carbon monoxide (p = 0.023). Conclusion: Pi10, as a biomaker of quantitative CT in fibrotic ILA patients, can reveal that smoking affects airway remodeling.
本研究旨在评估 Pi10 在胸部 CT 中对有纤维化间质肺异常（纤维化 ILA）的患者的作用，依据是累积吸烟量。
我们回顾性评估了 54 名纤维化 ILA 患者和 18 名健康不吸烟者（对照组），他们均接受了非增强 CT 和肺功能检查。我们对纤维化 ILA 患者的胸部 CT 中的气道变化（内腔面积、气道内参数、气道壁厚度、Pi10、偏度和峰度）进行了定量分析，并根据包年将纤维化 ILA 患者分为轻、中、重度吸烟组。通过单向方差分析比较三组纤维化 ILA 患者与对照组之间的气道变化数据和肺功能检查结果。
对照组的平均偏度（2.58 ± 0.36）和峰度（7.64 ± 2.36）明显不同于纤维化 ILA 患者的（1.89 ± 0.37 和 3.62 ± 1.70，分别为 p < 0.001）。在纤维化 ILA 组中，仅重度吸烟者的 Pi10 显著增加（平均增加 0.04，p = 0.013），节段性支气管的气道壁厚度增加（平均增加 0.06mm，p = 0.005），一氧化碳弥散量降低（p = 0.023）。
Pi10 作为纤维化 ILA 患者定量 CT 的生物标志物，可以揭示吸烟对气道重塑的影响。
