Akinyede Kolajo Adedamola, Hughes Gail Denise, Ekpo Okobi Eko, Oguntibeju Oluwafemi Omoniyi
Department of Medical Bioscience, University of the Western Cape, Bellville, Cape Town 7530, South Africa.
Department of Science Technology, Biochemistry Unit, The Federal Polytechnic P.M.B.5351, Ado Ekiti 360231, Nigeria.
Plants (Basel). 2022 Apr 7;11(8):998. doi: 10.3390/plants11080998.
Mill. (Asteraceae) is a plant genus comprising distinctively of aromatic plants of about 500-600 species. Since most of these plants have not been previously studied, extensive profiling helps to validate their folkloric uses and determine their potential value as sources of plant-derived drug candidates. This study, therefore, aims to investigate the antioxidant activity (DPPH, NO, FRAP); total antioxidant capacity, total phenolic, total flavonoid, and fatty acid compositions of the aqueous acetone extracts from four plants namely, , and . The results obtained showed that the extract had the best DPPH radical scavenging activity (IC = 11.85 ± 3.20 µg/mL) and extract had the best nitric oxide scavenging activity (IC = 20.81 ± 3.73 µg/mL), while Schrank extract (0.636 ± 0.005 µg/mL) demonstrated the best ferrous reducing power, all of which are comparable with results from ascorbic acid used as the standard. The IC values of the radical scavenging activity ranged from 11.85-41.13 µg/mL (DPPH), 20.81-36.19 µg/mL (NO), and 0.505-0.636 µg/mL (FRAP), for all the plants studied. The has the highest total antioxidant capacity (48.50 ± 1.55 mg/g), highest total phenolic content (54.69 ± 0.23 mg/g), and highest total flavonoid content (56.19 ± 1.01 mg/g) compared with other species. The fatty acid methyl esters were analysed using gas chromatography-mass spectrometry (GC-MS). The results obtained showed variations in the fatty acid composition of the plant extracts, with having the highest saturated fatty acid (SFA) content (7184 µg/g) and polyunsaturated fatty acid (PUFA) content (7005.5 µg/g). In addition, had the highest monounsaturated fatty acid (MUFA) content (1150.3 µg/g), while had the highest PUFA:SFA ratio of 1.202. In conclusion, the findings from this study revealed that Schrank, , , are repositories of natural bioactive compounds with potential health-promoting benefits that need to be investigated, for both their antioxidant activity in a number of disease conditions and for further exploration in drug discovery and development projects.
米尔（菊科）是一个植物属，由约500 - 600种具有独特香气的植物组成。由于这些植物中的大多数此前尚未得到研究，广泛的分析有助于验证它们在民间的用途，并确定它们作为植物源候选药物来源的潜在价值。因此，本研究旨在调查四种植物，即[此处植物名称缺失]、[此处植物名称缺失]、[此处植物名称缺失]和[此处植物名称缺失]的水丙酮提取物的抗氧化活性（DPPH、NO、FRAP）；总抗氧化能力、总酚类、总黄酮类和脂肪酸组成。所得结果表明，[此处植物名称缺失]提取物具有最佳的DPPH自由基清除活性（IC = 11.85 ± 3.20 µg/mL），[此处植物名称缺失]提取物具有最佳的一氧化氮清除活性（IC = 20.81 ± 3.73 µg/mL），而[此处植物名称缺失]施兰克提取物（0.636 ± 0.005 µg/mL）表现出最佳的亚铁还原能力，所有这些均与用作标准的抗坏血酸的结果相当。所有研究植物的自由基清除活性的IC值范围为11.85 - 41.13 µg/mL（DPPH）、20.81 - 36.19 µg/mL（NO）和0.505 - 0.636 µg/mL（FRAP）。与其他物种相比，[此处植物名称缺失]具有最高的总抗氧化能力（48.50 ± 1.55 mg/g）、最高的总酚含量（54.69 ± 0.23 mg/g）和最高的总黄酮含量（56.19 ± 1.01 mg/g）。使用气相色谱 - 质谱联用仪（GC - MS）分析脂肪酸甲酯。所得结果表明植物提取物的脂肪酸组成存在差异，[此处植物名称缺失]具有最高的饱和脂肪酸（SFA）含量（7184 µg/g）和多不饱和脂肪酸（PUFA）含量（7005.5 µg/g）。此外，[此处植物名称缺失]具有最高的单不饱和脂肪酸（MUFA）含量（1150.3 µg/g），而[此处植物名称缺失]具有最高的PUFA:SFA比值1.202。总之，本研究结果表明，[此处植物名称缺失]施兰克、[此处植物名称缺失]、[此处植物名称缺失]、[此处植物名称缺失]是天然生物活性化合物的储存库，具有潜在的促进健康益处，需要针对它们在多种疾病状况下的抗氧化活性以及在药物发现和开发项目中的进一步探索进行研究。
