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Castleman病中的“浆细胞样T细胞”。免疫组织学表型。

"Plasmacytoid T cells" in Castleman's disease. Immunohistologic phenotype.

作者信息

Harris N L, Bhan A K

出版信息

Am J Surg Pathol. 1987 Feb;11(2):109-13. doi: 10.1097/00000478-198702000-00004.

DOI:10.1097/00000478-198702000-00004
PMID:3544885
Abstract

Plasmacytoid T cells in two cases of Castleman's disease were stained with a panel of monoclonal antibodies to hematopoietic cell-associated antigens, using an immunoperoxidase technique on frozen sections. The immunohistologic phenotype of these cells was T4/Leu-3+, HLA-DR+, T1/Leu-1-, T3/Leu-4-, T8/Leu-2-, T11/Leu-5-, B1-, B2-, Leu-14-, Ig-, CALLA-, OKM1-, Leu-M1-. In contrast to plasma cells of B lineage, plasmacytoid T cells were T200+, T10-. The phenotype was similar to that of two previously reported lymphomas of plasmacytoid T cells. Plasmacytoid T cells appear to be a unique subset of lymphoid cells, whose function remains to be established.

摘要

采用免疫过氧化物酶技术,对两例Castleman病中的浆细胞样T细胞进行冷冻切片,并使用一组针对造血细胞相关抗原的单克隆抗体进行染色。这些细胞的免疫组织学表型为T4/Leu-3+、HLA-DR+、T1/Leu-1-、T3/Leu-4-、T8/Leu-2-、T11/Leu-5-、B1-、B2-、Leu-14-、Ig-、CALLA-、OKM1-、Leu-M1-。与B淋巴细胞系的浆细胞不同,浆细胞样T细胞为T200+、T10-。该表型与之前报道的两例浆细胞样T细胞淋巴瘤相似。浆细胞样T细胞似乎是一类独特的淋巴细胞亚群,其功能尚待确定。

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