Jacobs G H, Aikawa M, Milhous W K, Rabbege J R
Am J Trop Med Hyg. 1987 Jan;36(1):9-14. doi: 10.4269/ajtmh.1987.36.9.
The ultrastructural changes induced by the administration of a recently developed antimalarial drug, mefloquine, were studied in mice infected with Plasmodium berghei and human erythrocytes infected with P. falciparum in vitro. Pronounced changes which occurred in both experiments comprised swelling of the parasites' food vacuoles with gradual loss of pigment granules, which did not form clumps as occurs with chloroquine. These findings suggest that the malarial parasites' food vacuole is the target of this drug.
在感染伯氏疟原虫的小鼠以及体外感染恶性疟原虫的人红细胞中，研究了最近开发的抗疟药物甲氟喹给药所引起的超微结构变化。两个实验中均出现的显著变化包括疟原虫食物泡肿胀，色素颗粒逐渐丢失，且不像使用氯喹时那样形成团块。这些发现表明疟原虫的食物泡是这种药物的作用靶点。
