在接受雷珠单抗治疗的新生血管性年龄相关性黄斑变性（nAMD）中，光学相干断层扫描（OCT）发现的意义不确定的结果作为预后因素。
Findings of uncertain significance by optical coherence tomography (OCT) as prognostic factors in neovascular age-related macular degeneration (nAMD) treated with ranibizumab.
作者信息
Hayashi-Mercado Ricardo, Pérez-Montaño Carla, Reyes-Sánchez Jaime, Ramírez-Estudillo Abel
机构信息
Retina and Vitreous Department, Fundación Hospital Nuestra Señora de La Luz, Ezequiel Montes 135, 06030, Mexico City, Mexico.
Department of Population and Publica Health Sciences, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, 90033, Los Angeles, CA, USA.
出版信息
Int J Retina Vitreous. 2022 Apr 21;8(1):29. doi: 10.1186/s40942-022-00379-z.
BACKGROUND
Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process.
METHODS
The aim of this retrospective study was to evaluate the association between visual outcome and the presence of findings of uncertain significance by optical coherence tomography (OCT) pre and post loading dose in patients with neovascular age-related macular degeneration (nAMD) treated with ranibizumab.
RESULTS
Univariate analysis revealed a higher letter gain in those with presence of onion sign (+ 5.6 ETDRS letters, p = 0.04) absence of prechoroidal cleft (+ 3.7 ETDRS letters, p = 0.04), intraretinal pseudocysts (+4.8 ETDRS letters, p = 0.002), subretinal pseudocysts (+ 4.6 ETDRS letters, p = 0.005) and choroidal caverns (+ 4.4 ETDRS, letters p = 0.0065).
CONCLUSIONS
The presence of prechoroidal cleft, intraretinal and subretinal pseudocysts and choroidal caverns were associated with lower visual gains. Moreover, we found that the onion sign is related as a biomarker of good prognostics. Trial registration Registration number: 2021R13B2. Date of registration: 01/05/2020.
背景
生物标志物对个性化医疗具有巨大潜力，因为从诊断或病情进展标志物获得的信息可用于为个体量身定制治疗方案，从而在疾病过程中进行高效干预。
方法
这项回顾性研究的目的是评估在接受雷珠单抗治疗的新生血管性年龄相关性黄斑变性（nAMD）患者中，光学相干断层扫描（OCT）在负荷剂量前后出现意义不确定的检查结果与视觉预后之间的关联。
结果
单因素分析显示，存在洋葱征的患者字母视力提高更多（+5.6个早期糖尿病性视网膜病变研究组字母，p = 0.04），无脉络膜前裂的患者（+3.7个早期糖尿病性视网膜病变研究组字母，p = 0.04），视网膜内假性囊肿（+4.8个早期糖尿病性视网膜病变研究组字母，p = 0.002），视网膜下假性囊肿（+4.6个早期糖尿病性视网膜病变研究组字母，p = 0.005）和脉络膜海绵状血管瘤（+4.4个早期糖尿病性视网膜病变研究组字母，p = 0.0065）。
结论
脉络膜前裂、视网膜内和视网膜下假性囊肿以及脉络膜海绵状血管瘤的存在与较低的视力提高相关。此外，我们发现洋葱征是良好预后的生物标志物。试验注册 注册号：2021R13B2。注册日期：2020年5月1日。
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