Department of Oral Diagnosis and Medicine, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
World J Surg Oncol. 2022 Apr 21;20(1):127. doi: 10.1186/s12957-022-02592-4.
Basal cell carcinoma (BCC) is the most common cancer worldwide. Most of BCCs can be detected in the early stages and are generally well controlled with local resection. Despite the high incidence of BCC, metastasis is rarely observed. Metastatic BCCs generally have an aggressive phenotype and are refractory to conventional treatment.
We describe a rare case of BCC in which a series of local relapses culminated in metastasis into the oral cavity 10 years after the first diagnosis of cutaneous BCC. We performed surgical resection and postoperative radiotherapy in this patient; 11 months after the final course of radiotherapy, the BCC remains stable, and the patient continues to be monitored regularly.
Because metastatic BCC is refractory to current treatment and difficult to control, his treatment history and the pathohistological features of BCC had to be considered in posttreatment planning.
基底细胞癌(BCC)是世界范围内最常见的癌症。大多数 BCC 可以在早期被发现,并且通常通过局部切除得到很好的控制。尽管 BCC 的发病率很高,但转移很少见。转移性 BCC 通常具有侵袭性表型,对常规治疗具有抗药性。
我们描述了一例罕见的 BCC 病例,该患者在首次诊断为皮肤 BCC 10 年后,一系列局部复发最终导致转移至口腔。我们对该患者进行了手术切除和术后放疗;在最后一次放疗后 11 个月,BCC 仍然稳定,患者继续定期监测。
由于转移性 BCC 对当前治疗具有抗药性且难以控制,因此在制定治疗后计划时必须考虑到他的治疗史和 BCC 的病理特征。