Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang East Road, Haizhu District, Guangzhou, 510260, Guangdong, China.
Department of Oncology, HaploX Biotechnology, Co., Ltd., Shenzhen, 518057, China.
Hum Genomics. 2022 Apr 22;16(1):14. doi: 10.1186/s40246-022-00386-z.
Gastric cancer (GC) shows high metastasis and low survival. RNA modification writers play critical roles in tumor development. This study examined the clinical significance of RNA modification writers in GC prognosis based on four types of adenosine modifications (mA, mA, APA and A-to-I).
Writers demonstrated high mutation and expression in GC patients. Different expressions of 26 RNA modification writers were differentially associated with GC prognosis. High-WM score group appeared worse overall survival, higher immune infiltration and activation of EMT pathways than low-WM score group. WM score was correlated with both miRNAs-targeted signaling pathways and patients' sensitivity to chemotherapeutic drugs and efficacy of immunotherapy.
This study further revealed the close association between adenosine-related RNA modifications and progression of GC. A cross talk between EMT and RNA modification was identified to be one of the mechanisms underlying GC development. Our WM scoring system could serve as a clinical indicator for predicting GC prognosis. Importantly, the WM score could guide personalized treatments such as chemotherapy and immunotherapy for GC patients.
胃癌（GC）具有高转移和低生存率的特点。RNA 修饰写入器在肿瘤发展中起着关键作用。本研究基于四种腺苷修饰（mA、mAm、APA 和 A-to-I），探讨了 RNA 修饰写入器在 GC 预后中的临床意义。
在 GC 患者中，写入器表现出高突变和高表达。26 种 RNA 修饰写入器的不同表达与 GC 预后差异相关。高-WM 评分组的总生存期较差，免疫浸润和 EMT 途径的激活程度高于低-WM 评分组。WM 评分与 miRNA 靶向信号通路以及患者对化疗药物的敏感性和免疫治疗的疗效相关。
本研究进一步揭示了腺苷相关 RNA 修饰与 GC 进展之间的密切关系。鉴定到 EMT 与 RNA 修饰之间的串扰是 GC 发展的机制之一。我们的 WM 评分系统可以作为预测 GC 预后的临床指标。重要的是，WM 评分可以指导 GC 患者的化疗和免疫治疗等个性化治疗。
