Aghsaeifard Ziba, Latifi Marzieh, Bagherpour Farzaneh, Rahbar Maryam, Rahimzadeh Hormat, Namdari Farshad, Dialameh Hossein, Taheri Mahmoudi Mohsen, Dehghani Sanaz
Department of Internal Medicine, School of Medicine, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Organ Procurement Unit, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
SAGE Open Med Case Rep. 2022 Apr 14;10:2050313X221087567. doi: 10.1177/2050313X221087567. eCollection 2022.
Choriocarcinoma is a rare kind of cancer, which may be either gestational or non-gestational. Choriocarcinoma is responsible for about a quarter of all documented neoplastic aneurysms. It is a descriptive case report of choriocarcinoma transmission from a donor, following kidney donation. A 45-year-old woman got a kidney from a 25-year-old woman who was taken to the hospital due to a non-traumatic cerebral hemorrhage. She delivered a healthy baby 48 days before her brain death. The transplant was successfully done. Five weeks' post-transplantation, the recipient had pain and erythema in the surgical area. Regarding the high level of beta-human chorionic gonadotropin in her blood, diagnostic tests were performed. Following the confirmation of the cancer, a five-phase chemotherapy plan with various pharmaceutical regimens was initiated. Liver function test values rose after the final round of chemotherapy, and the patient developed hepatic encephalopathy. Considering the thrombocytopenia, dialysis, or hemoperfusion, which are normally performed to reduce liver enzymes, were not initiated. Finally, she died due to the hepatic failure and disseminated intravascular coagulation. Although the nephrologists disagree on the optimal course of treatment, it seems that nephrectomy would be helpful in such instances. Physicians should be aware of the possibility of transplant-related choriocarcinoma in female donors of reproductive age who die because of intracerebral brain hemorrhage for unclear reasons. Every donor must undergo a thorough examination. It is critical to get documents, clarify history, and interview relatives.
绒毛膜癌是一种罕见的癌症，可分为妊娠性或非妊娠性。绒毛膜癌约占所有已记录的肿瘤性动脉瘤的四分之一。这是一篇关于肾移植后供体绒毛膜癌传播的描述性病例报告。一名45岁女性接受了一名25岁女性捐赠的肾脏，后者因非创伤性脑出血被送往医院。她在脑死亡前48天产下一名健康婴儿。移植手术成功完成。移植后五周，受者手术区域出现疼痛和红斑。鉴于其血液中β-人绒毛膜促性腺激素水平较高，进行了诊断测试。确诊癌症后，启动了一个包含多种药物方案的五阶段化疗计划。最后一轮化疗后肝功能测试值升高，患者出现肝性脑病。考虑到血小板减少，通常用于降低肝酶的透析或血液灌流未启动。最终，她因肝衰竭和弥散性血管内凝血死亡。尽管肾病学家对最佳治疗方案存在分歧，但在这种情况下肾切除术似乎会有帮助。医生应意识到，对于因不明原因脑出血死亡的育龄女性供体，存在移植相关绒毛膜癌的可能性。每个供体都必须接受全面检查。获取文件、澄清病史并询问亲属至关重要。
