Mattoli S, Foresi A, Corbo G M, Valente S, Culla G, Toscano L, Bevignani G, Porcarelli M G, Patalano F, Ciappi G
Ann Allergy. 1987 Feb;58(2):134-40.
Twenty asthmatic subjects had two successive methacholine challenges, two successive challenges with ultrasonically nebulized distilled water (UNDW) and an UNDW followed by methacholine on three separate days. Only ten subjects showed a refractory period to repeated UNDW stimulation. Prior stimulation with UNDW provoked increased methacholine responsiveness in the non-refractory group and a more rapid recovery from methacholine-induced bronchoconstriction in the refractory subset.
20名哮喘患者在三个不同日期分别接受了两次连续的乙酰甲胆碱激发试验、两次连续的超声雾化蒸馏水（UNDW）激发试验以及一次UNDW激发试验后再进行乙酰甲胆碱激发试验。只有10名受试者对重复的UNDW刺激表现出不应期。在非不应期组中，先前的UNDW刺激会引发乙酰甲胆碱反应性增加，而在不应期亚组中，乙酰甲胆碱诱导的支气管收缩恢复更快。
