Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Department of SICU, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Oxid Med Cell Longev. 2022 Apr 11;2022:7805115. doi: 10.1155/2022/7805115. eCollection 2022.
Thioredoxin-interacting protein (TXNIP) was originally named vitamin D upregulated protein-1 (VDUP1) because of its ability to bind to thioredoxin (TRX) and inhibit TRX function and expression. TXNIP is an alpha-arrestin protein that is essential for redox homeostasis in the human body. TXNIP may act as a double-edged sword in the cell. The balance of TXNIP is crucial. A study has shown that TXNIP can travel between diverse intracellular locations and bind to different proteins to play different roles under oxidative stress. The primary function of TXNIP is to induce apoptosis or pyroptosis under oxidative stress. TXNIP also inhibits proliferation and migration in cancer cells, although TXNIP levels decrease, and function diminishes in various cancers. In this review, we summarized the main structure, binding proteins, pathways, and the role of TXNIP in diseases, aiming to explore the double-edged sword role of TXNIP, and expect it to be helpful for future treatment using TXNIP as a therapeutic target.
硫氧还蛋白相互作用蛋白（TXNIP）最初因其与硫氧还蛋白（TRX）结合并抑制 TRX 功能和表达的能力而被命名为维生素 D 上调蛋白 1（VDUP1）。TXNIP 是一种 α-抑制蛋白，对人体的氧化还原稳态至关重要。TXNIP 在细胞中可能充当双刃剑。TXNIP 的平衡至关重要。一项研究表明，TXNIP 可以在氧化应激下在不同的细胞内位置之间移动，并与不同的蛋白质结合，以发挥不同的作用。TXNIP 的主要功能是在氧化应激下诱导细胞凋亡或细胞焦亡。TXNIP 还抑制癌细胞的增殖和迁移，尽管 TXNIP 水平降低，并且在各种癌症中其功能减弱。在这篇综述中，我们总结了 TXNIP 的主要结构、结合蛋白、途径以及在疾病中的作用，旨在探讨 TXNIP 的双刃剑作用，并期望它作为治疗靶点使用 TXNIP 进行未来治疗有所帮助。
