Dardick I, Caldwell D R, Silver S S, Tubbs R R
Arch Pathol Lab Med. 1987 Feb;111(2):130-8.
Precise morphologic data on the relationship of diffuse well-differentiated lymphocytic lymphoma (DWDLL) to other non-Hodgkin's lymphomas (NHLs) are lacking in current classifications of lymphomas. Morphometry of plastic-embedded tissues describes details of the mean nuclear parameters and distribution of lymphocyte-types in 14 cases of DWDLL in nodal and extranodal sites. The results indicate that the proportion of small (unstimulated or nontransformed) lymphocytes in DWDLL varies from 50% to 86%. The mean nuclear area of small lymphocytes in DWDLL is either within the size range or somewhat smaller, and many examples are more irregular in shape, than the small lymphocytes in germinal centers that are morphologically comparable with the majority of lymphocytes in DWDLL and mantle zones. The morphologic relationship of DWDLL to other NHLs, Hodgkin's disease, and paracortical, mantle, and germinal center lymphocytes in lymphoid-reactive hyperplasia was established by morphometric analysis of the nuclear profiles of small lymphocytes. The small (nontransformed) lymphocytes in those subtypes of NHL other than DWDLL have abnormally small and more irregular nuclear profiles than those in normal small lymphocytes, or the small-lymphocyte population of Hodgkin's disease. Such findings may be of diagnostic significance to pathologists.
在当前淋巴瘤分类中，缺乏关于弥漫性高分化淋巴细胞淋巴瘤（DWDLL）与其他非霍奇金淋巴瘤（NHL）关系的确切形态学数据。对塑料包埋组织进行形态测量，描述了14例淋巴结和结外部位DWDLL中平均核参数及淋巴细胞类型分布的细节。结果表明，DWDLL中小（未受刺激或未转化）淋巴细胞的比例在50%至86%之间。DWDLL中小淋巴细胞的平均核面积要么在大小范围内，要么略小，而且许多例子的形状比生发中心的小淋巴细胞更不规则，生发中心的小淋巴细胞在形态上与DWDLL和套区中的大多数淋巴细胞相当。通过对小淋巴细胞核轮廓进行形态测量分析，确定了DWDLL与其他NHL、霍奇金病以及淋巴反应性增生中的副皮质、套区和生发中心淋巴细胞之间的形态学关系。除DWDLL外的其他NHL亚型中的小（未转化）淋巴细胞，其核轮廓比正常小淋巴细胞或霍奇金病的小淋巴细胞群体异常小且更不规则。这些发现可能对病理学家具有诊断意义。
