2015-2017 年全球产碳青霉烯酶大肠埃希菌的基因组流行病学研究。
Genomic Epidemiology of Global Carbapenemase-Producing Escherichia coli, 2015-2017.
出版信息
Emerg Infect Dis. 2022 May;28(5):924-31. doi: 10.3201/eid2805.212535.
Abstract
We describe the global molecular epidemiology of 229 carbapenemase-producing Escherichia coli in 36 countries during 2015-2017. Common carbapenemases were oxacillinase (OXA) 181 (23%), New Delhi metallo-β-lactamase (NDM) 5 (20%), OXA-48 (17%), Klebsiella pneumoniae carbapenemase 2 (15%), and NDM-1 (10%). We identified 5 dominant sequence types (STs); 4 were global (ST410, ST131, ST167, and ST405), and 1 (ST1284) was limited to Turkey. OXA-181 was frequent in Jordan (because of the ST410-B4/H24RxC subclade) and Turkey (because of ST1284). We found nearly identical IncX3-bla plasmids among 11 STs from 12 countries. NDM-5 was frequent in Egypt, Thailand (linked with ST410-B4/H24RxC and ST167-B subclades), and Vietnam (because of ST448). OXA-48 was common in Turkey (linked with ST11260). Global K. pneumoniae carbapenemases were linked with ST131 C1/H30 subclade and NDM-1 with various STs. The global carbapenemase E. coli population is dominated by diverse STs with different characteristics and varied geographic distributions, requiring ongoing genomic surveillance.
摘要
我们描述了 2015-2017 年 36 个国家 229 株碳青霉烯酶产生大肠埃希菌的全球分子流行病学。常见的碳青霉烯酶有 oxacillinase（OXA）181（23%）、New Delhi metallo-β-lactamase（NDM）5（20%）、OXA-48（17%）、Klebsiella pneumoniae carbapenemase 2（15%）和 NDM-1（10%）。我们鉴定了 5 种主要的序列型（ST）；其中 4 种是全球性的（ST410、ST131、ST167 和 ST405），1 种（ST1284）仅限于土耳其。OXA-181 在约旦（因为 ST410-B4/H24RxC 亚群）和土耳其（因为 ST1284）很常见。我们在来自 12 个国家的 11 种 ST 中发现了几乎相同的 IncX3-bla 质粒。NDM-5 在埃及、泰国（与 ST410-B4/H24RxC 和 ST167-B 亚群有关）和越南（因为 ST448）很常见。OXA-48 在土耳其很常见（与 ST11260 有关）。全球 K. pneumoniae carbapenemases 与 ST131 C1/H30 亚群有关，而 NDM-1 与各种 ST 有关。全球碳青霉烯酶大肠埃希菌种群由具有不同特征和不同地理分布的不同 ST 主导，需要进行持续的基因组监测。
相似文献
1
Genomic Epidemiology of Global Carbapenemase-Producing Escherichia coli, 2015-2017.2015-2017 年全球产碳青霉烯酶大肠埃希菌的基因组流行病学研究。
Emerg Infect Dis. 2022 May;28(5):924-31. doi: 10.3201/eid2805.212535.
2
Increasing New Delhi metallo-β-lactamase-positive Escherichia coli among carbapenem non-susceptible Enterobacteriaceae in Taiwan during 2016 to 2018.2016 年至 2018 年期间，台湾耐碳青霉烯类肠杆菌科细菌中新型德里金属β-内酰胺酶阳性大肠埃希菌的增加。
Sci Rep. 2021 Jan 28;11(1):2609. doi: 10.1038/s41598-021-82166-8.
3
Dissemination of an international high-risk clone of Escherichia coli ST410 co-producing NDM-5 and OXA-181 carbapenemases in Seoul, Republic of Korea.韩国首尔市出现同时产 NDM-5 和 OXA-181 碳青霉烯酶的肠杆菌科 ST410 国际高危克隆的传播。
Int J Antimicrob Agents. 2021 Dec;58(6):106448. doi: 10.1016/j.ijantimicag.2021.106448. Epub 2021 Oct 11.
4
Clinically relevant sequence types of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae detected in Finnish wastewater in 2021-2022.2021-2022 年芬兰废水中检出的具有临床相关性的产碳青霉烯酶大肠埃希菌和肺炎克雷伯菌的序列型。
Antimicrob Resist Infect Control. 2024 Jan 30;13(1):14. doi: 10.1186/s13756-024-01370-z.
5
Plasmid analysis of Escherichia coli isolates from South Korea co-producing NDM-5 and OXA-181 carbapenemases.韩国产 NDM-5 和 OXA-181 碳青霉烯酶的大肠杆菌分离株的质粒分析。
Plasmid. 2019 Jul;104:102417. doi: 10.1016/j.plasmid.2019.102417. Epub 2019 May 28.
6
Characterization of Carbapenem-Resistant Enterobacteriaceae Clinical Isolates in Al Thawra University Hospital, Sana'a, Yemen.也门萨那 Al Thawra 大学医院耐碳青霉烯肠杆菌科临床分离株的特征。
Microb Drug Resist. 2020 Mar;26(3):211-217. doi: 10.1089/mdr.2018.0443. Epub 2019 Aug 9.
7
Prevalence and Characteristics of Carbapenemase-Producing Enterobacteriaceae in Three Tertiary-Care Korean University Hospitals between 2017 and 2018.2017 年至 2018 年期间，三家韩国三级保健大学医院中产碳青霉烯酶肠杆菌科的流行情况和特征。
Jpn J Infect Dis. 2020 Nov 24;73(6):431-436. doi: 10.7883/yoken.JJID.2020.043. Epub 2020 May 29.
8
OXA-181-Like Carbapenemases in Klebsiella pneumoniae ST14, ST15, ST23, ST48, and ST231 from Septicemic Neonates: Coexistence with NDM-5, Resistome, Transmissibility, and Genome Diversity.肺炎克雷伯菌 ST14、ST15、ST23、ST48 和 ST231 中的 OXA-181 类碳青霉烯酶：与 NDM-5、耐药组、传播性和基因组多样性共存于败血症新生儿中。
mSphere. 2021 Jan 13;6(1):e01156-20. doi: 10.1128/mSphere.01156-20.
9
A Decade-Long Evaluation of Neonatal Septicaemic Escherichia coli: Clonal Lineages, Genomes, and New Delhi Metallo-Beta-Lactamase Variants.长达十年的新生儿败血症大肠杆菌评估：克隆谱系、基因组和新德里金属β-内酰胺酶变体。
Microbiol Spectr. 2023 Aug 17;11(4):e0521522. doi: 10.1128/spectrum.05215-22. Epub 2023 Jun 27.
10
A Nationwide Plasmidome Surveillance in Thailand Reveals a Limited Variety of New Delhi Metallo-β-Lactamase-Producing Carbapenem-Resistant Clones and Spreading Plasmids.泰国全国范围的质粒组监测揭示了有限数量的新德里金属β-内酰胺酶产生碳青霉烯类耐药克隆和传播质粒。
J Clin Microbiol. 2022 Dec 21;60(12):e0108022. doi: 10.1128/jcm.01080-22. Epub 2022 Nov 29.
引用本文的文献
1
Detection and Genomic Characteristics of NDM-19- and QnrS11-Producing O101:H5 Strain Phylogroup A: ST167 from a Poultry Farm in Egypt.埃及一家家禽养殖场产NDM-19和QnrS11的O101:H5血清型A系群：ST167菌株的检测及基因组特征
Microorganisms. 2025 Jul 29;13(8):1769. doi: 10.3390/microorganisms13081769.
2
How to measure bacterial genome plasticity? A novel index helps gather insights on pathogens.如何测量细菌基因组可塑性？一种新指标有助于深入了解病原体。
Microb Genom. 2025 Aug;11(8). doi: 10.1099/mgen.0.001459.
3
Comprehensive antibiotic resistome comparison of from irritable bowel syndrome and ulcerative colitis.肠易激综合征和溃疡性结肠炎患者的综合抗生素耐药基因组比较
Curr Res Microb Sci. 2025 Apr 30;8:100398. doi: 10.1016/j.crmicr.2025.100398. eCollection 2025.
4
Nationwide surveillance of carbapenem-resistant Gram-negative pathogens in the Lebanese environment.黎巴嫩环境中耐碳青霉烯革兰氏阴性病原体的全国性监测。
Appl Environ Microbiol. 2025 Jul 23;91(7):e0193224. doi: 10.1128/aem.01932-24. Epub 2025 Jun 10.
5
The emerging concern of IMP variants being resistant to the only IMP-type metallo-β-lactamase inhibitor, xeruborbactam.对 IMP 变体对唯一的 IMP 型金属β-内酰胺酶抑制剂西鲁巴坦产生耐药性这一问题的新关注。
Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0029725. doi: 10.1128/aac.00297-25. Epub 2025 Jun 9.
6
Mobile genetic elements of global Escherichia coli ST131 clades with carbapenemases.携带碳青霉烯酶的全球大肠杆菌ST131进化枝的可移动遗传元件
Eur J Clin Microbiol Infect Dis. 2025 Jun 7. doi: 10.1007/s10096-025-05187-5.
7
Escherichia coli causing bloodstream infections in Mexican paediatric patients: molecular typing, antimicrobial resistance, virulence factors, and clinical features.引起墨西哥儿科患者血流感染的大肠杆菌：分子分型、抗菌药物耐药性、毒力因子及临床特征
BMC Infect Dis. 2025 May 27;25(1):764. doi: 10.1186/s12879-025-11163-3.
8
Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolates.导致产NDM样的大肠杆菌ST167临床分离株对头孢地尔产生高水平耐药的联合耐药机制。
Eur J Clin Microbiol Infect Dis. 2025 May 27. doi: 10.1007/s10096-025-05166-w.
9
Rapid Simultaneous Detection of the Clinically Relevant Carbapenemase Resistance Genes KPC, OXA48, VIM and NDM with the Newly Developed Ready-to-Use qPCR CarbaScan LyoBead.使用新开发的即用型qPCR CarbaScan冻干珠快速同时检测临床相关的碳青霉烯酶耐药基因KPC、OXA48、VIM和NDM
Int J Mol Sci. 2025 Jan 30;26(3):1218. doi: 10.3390/ijms26031218.
10
Companions in antimicrobial resistance: examining transmission of common antimicrobial-resistant organisms between people and their dogs, cats, and horses.抗菌药物耐药性的伙伴关系：研究常见抗菌药物耐药菌在人与他们的狗、猫和马之间的传播情况。
Clin Microbiol Rev. 2025 Mar 13;38(1):e0014622. doi: 10.1128/cmr.00146-22. Epub 2025 Jan 24.
本文引用的文献
1
Population Dynamics of Escherichia coli Causing Bloodstream Infections over Extended Time Periods.不同时期引起血流感染的大肠杆菌的种群动态。
mSphere. 2021 Dec 22;6(6):e0095621. doi: 10.1128/msphere.00956-21.
2
The role of potentiating mutations in the evolution of pandemic Escherichia coli clones.增强突变在大流行大肠杆菌克隆进化中的作用。
Eur J Clin Microbiol Infect Dis. 2021 Nov 17. doi: 10.1007/s10096-021-04359-3.
3
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study.不同全球地区患者中耐碳青霉烯类肺炎克雷伯菌的临床结局和细菌特征（CRACKLE-2）：一项前瞻性、多中心、队列研究。
Lancet Infect Dis. 2022 Mar;22(3):401-412. doi: 10.1016/S1473-3099(21)00399-6. Epub 2021 Nov 9.
4
Characterizing social-ecological context and success factors of antimicrobial resistance interventions across the One Health spectrum: analysis of 42 interventions targeting E. coli.描述贯穿“同一健康”领域的抗微生物药物耐药性干预措施的社会-生态背景和成功因素：针对大肠杆菌的 42 项干预措施的分析
BMC Infect Dis. 2021 Aug 26;21(1):873. doi: 10.1186/s12879-021-06483-z.
5
Global molecular epidemiology of carbapenem-resistant Escherichia coli (2002-2017).耐碳青霉烯类大肠杆菌的全球分子流行病学（2002 - 2017年）
Eur J Clin Microbiol Infect Dis. 2021 Jul 19. doi: 10.1007/s10096-021-04310-6.
6
Population-based surveillance of Enterobacter cloacae complex causing blood stream infections in a centralized Canadian region.以人群为基础的加拿大集中区域肠杆菌科复合群引起血流感染的监测。
Eur J Clin Microbiol Infect Dis. 2022 Jan;41(1):119-125. doi: 10.1007/s10096-021-04309-z. Epub 2021 Jul 14.
7
Inclusion of next-generation leaders and cost-effective precision diagnostic techniques are vital in combatting antimicrobial resistance in low- and middle-income countries.吸纳下一代领导人以及采用具有成本效益的精准诊断技术对于在低收入和中等收入国家对抗抗菌药物耐药性至关重要。
JAC Antimicrob Resist. 2020 Jun 23;2(2):dlaa032. doi: 10.1093/jacamr/dlaa032. eCollection 2020 Jun.
8
Treatment for carbapenem-resistant Enterobacterales infections: recent advances and future directions.碳青霉烯类耐药肠杆菌科感染的治疗：最新进展和未来方向。
Eur J Clin Microbiol Infect Dis. 2021 Oct;40(10):2053-2068. doi: 10.1007/s10096-021-04296-1. Epub 2021 Jun 24.
9
Epidemiology of Carbapenem Resistance Determinants Identified in Meropenem-Nonsusceptible Collected as Part of a Global Surveillance Program, 2012 to 2017.2012 年至 2017 年全球监测计划中收集的美罗培南中介耐药碳青霉烯类耐药决定因子的流行病学研究。
Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0200020. doi: 10.1128/AAC.02000-20.
10
Emerging Antimicrobial-Resistant High-Risk Klebsiella pneumoniae Clones ST307 and ST147.出现的具有抗药性的高风险肺炎克雷伯菌克隆株 ST307 和 ST147。
Antimicrob Agents Chemother. 2020 Sep 21;64(10). doi: 10.1128/AAC.01148-20.
Zotero 插件