Department of Cardiology, the Affiliated Hospital of Putian University, Putian, China.
Medicine (Baltimore). 2022 Mar 11;101(10):e28934. doi: 10.1097/MD.0000000000028934.
To observe whether obstructive sleep apnea syndrome (OSAS) can aggravate the cognitive dysfunction of patients with hypertension (HTN), and to explore other risk factors.One hundred one hypertensive patients were selected for information collection. After the polysomnography test, they were divided into HTN-obstructive sleep apnea (OSA) and HTN groups. The Montreal cognitive assessment and the mini-mental state examination scales were used to appraise the patients' cognitive function. Logistic regressive analysis was used to determine the risk factors of cognitive dysfunction in patients with HTN.Compared with the HTN patients, HTN-OSA patients performed worse in mini-mental state examination (25.5 ± 2.9 vs 23.5 ± 3.2; P = .01) and Montreal cognitive assessment (28 ± 1.58 vs 21.2 ± 3.96; P = .003), and patients in the HTN-OSA group seemed more likely to suffer from dementia (31% vs 66%; P < .01). The apnea-hypopnea index (AHI) in the HTN group was lower than HTN-OSA group. Through multivariate logistic regression analysis, we can found that alcohol drinking, body mass index, long-term medication, diabetes, hypercholesterolemia, coronary heart disease, and OSAS were the independent risk factors of cognitive dysfunction in patients with HTN.OSAS can aggravate the cognitive dysfunction of hypertensive patients, besides, drinking, high-body mass index, long-term medication, diabetes, hypercholesterolemia, and coronary heart disease were also the risk factors of cognitive dysfunction in patients with hypertension. The cognitive dysfunction of patients with HTN can benefit from sleep apnea treatment.
观察阻塞性睡眠呼吸暂停综合征（OSAS）是否会加重高血压（HTN）患者的认知功能障碍，并探讨其他危险因素。
选择 101 例高血压患者进行信息收集。经过多导睡眠图检查后，将患者分为 HTN-阻塞性睡眠呼吸暂停（OSA）和 HTN 组。采用蒙特利尔认知评估和简易精神状态检查量表评估患者的认知功能。采用 Logistic 回归分析确定 HTN 患者认知功能障碍的危险因素。
与 HTN 患者相比，HTN-OSA 患者在简易精神状态检查（25.5±2.9 与 23.5±3.2；P=0.01）和蒙特利尔认知评估（28±1.58 与 21.2±3.96；P=0.003）方面表现更差，HTN-OSA 组患者更有可能患有痴呆（31%与 66%；P<0.01）。HTN 组的呼吸暂停低通气指数（AHI）低于 HTN-OSA 组。通过多变量 logistic 回归分析，我们发现饮酒、体重指数、长期用药、糖尿病、高胆固醇血症、冠心病和 OSAS 是高血压患者认知功能障碍的独立危险因素。
OSAS 可加重高血压患者的认知功能障碍，此外，饮酒、高体重指数、长期用药、糖尿病、高胆固醇血症和冠心病也是高血压患者认知功能障碍的危险因素。高血压患者的认知功能障碍可受益于睡眠呼吸暂停治疗。
