Department of Cardiology, Tianjin First Central Hospital, 300192 Tianjin, China.
J Integr Neurosci. 2023 Jun 29;22(4):83. doi: 10.31083/j.jin2204083.
Obstructive sleep apnea syndrome (OSAS) is a common clinical disease that seriously affects the quality of life and health of patients. This study aimed to explore the correlation between OSAS and cognitive dysfunction in elderly patients with hypertension.
A total of 106 elderly hypertensive patients were included and divided into OSAS group (n = 45) and non-OSAS group (n = 61), according to whether they combined with OSAS. OSAS was monitored with a portable polysomnography monitor by monitoring sleep and breathing. The cognitive dysfunction of the patients was evaluated using the Montreal Cognitive Assessment (MoCA). Basic data and MoCA scores of the patients were compared between the OSAS group and non-OSAS group. The correlation between OSAS and cognitive dysfunction in patients was evaluated using Pearson's correlation analysis.
The proportion of men (38 22, = 0.000), atrial fibrillation (31 19, = 0.000), body mass index (27.32 ± 3.85 21.27 ± 5.90, = 0.002), systolic pressure (167.76 ± 14.31 153.22 ± 12.79, = 0.008), homocysteine (29.71 ± 6.27 12.50 ± 4.19, = 0.005), cognitive dysfunction (15 10, = 0.042) in patients of the OSAS group were significantly higher compared to patients of the non-OSAS group. Visual space/executive ability (3.12 ± 1.23 4.75 ± 1.03, = 0.021), memory (2.48 ± 0.31 3.71 ± 0.42, = 0.039), attention (4.15 ± 1.21 5.12 ± 1.87, = 0.041), total MoCA scores (20.11 ± 5.09 25.76 ± 4.31, = 0.017) in patients in the OSAS group were significantly lower compared to patients in the non-OSAS group. OSAS was positively correlated with cognitive dysfunction in elderly patients with hypertension ( = 0.224, 0.05).
OSAS was positively correlated with cognitive dysfunction in elderly patients with hypertension, so OSAS could increase the risk of cognitive dysfunction through its own adverse effects or its accompanying disease status.
阻塞性睡眠呼吸暂停综合征（OSAS）是一种常见的临床疾病，严重影响患者的生活质量和健康。本研究旨在探讨老年高血压患者 OSAS 与认知功能障碍的相关性。
纳入 106 例老年高血压患者，根据是否合并 OSAS 将其分为 OSAS 组（n=45）和非 OSAS 组（n=61）。使用便携式多导睡眠监测仪监测睡眠和呼吸情况，监测 OSAS。采用蒙特利尔认知评估量表（MoCA）评估患者的认知功能障碍。比较 OSAS 组和非 OSAS 组患者的基本资料和 MoCA 评分。采用 Pearson 相关分析评估 OSAS 与患者认知功能障碍的相关性。
OSAS 组患者中男性（38/22， = 0.000）、心房颤动（31/19， = 0.000）、体质量指数（27.32±3.85比 21.27±5.90， = 0.002）、收缩压（167.76±14.31比 153.22±12.79， = 0.008）、同型半胱氨酸（29.71±6.27比 12.50±4.19， = 0.005）、认知功能障碍（15/10， = 0.042）的比例明显高于非 OSAS 组。OSAS 组患者的视空间/执行能力（3.12±1.23比 4.75±1.03， = 0.021）、记忆（2.48±0.31比 3.71±0.42， = 0.039）、注意力（4.15±1.21比 5.12±1.87， = 0.041）、MoCA 总分（20.11±5.09比 25.76±4.31， = 0.017）明显低于非 OSAS 组。OSAS 与老年高血压患者的认知功能障碍呈正相关（ = 0.224， 0.05）。
OSAS 与老年高血压患者的认知功能障碍呈正相关，因此 OSAS 可能通过自身的不良影响或伴发疾病状态增加认知功能障碍的风险。
