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MD2 AMP(K)s up the link between lipid accumulation and inflammation in NAFLD.

作者信息

Heldens Anneleen, Lefere Sander

机构信息

Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Liver Research Center Ghent, Ghent University, Ghent, Belgium.

Gut-Liver Immunopharmacology Unit, Department of Basic and Applied Medical Sciences, Liver Research Center Ghent, Ghent University, Ghent, Belgium.

出版信息

Clin Transl Med. 2022 Apr;12(4):e832. doi: 10.1002/ctm2.832.

DOI:10.1002/ctm2.832
PMID:35452173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9028087/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be52/9028087/5e6a934e6aad/CTM2-12-e832-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be52/9028087/5e6a934e6aad/CTM2-12-e832-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be52/9028087/5e6a934e6aad/CTM2-12-e832-g001.jpg

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本文引用的文献

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Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma.全基因组功能获得性筛选鉴定出 EZH2 介导的食管鳞癌对 PI3Kα 抑制剂的耐药性。
Clin Transl Med. 2022 May;12(5):e835. doi: 10.1002/ctm2.835.
2
MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease.MD2 缺乏通过调节非酒精性脂肪肝病中的 TBK1 来防止高脂肪饮食诱导的 AMPK 抑制和脂质积累。
Clin Transl Med. 2022 Mar;12(3):e777. doi: 10.1002/ctm2.777.
3
Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2.
运动诱导的鸢尾素通过与 MD2 的竞争性结合减少炎症并改善非酒精性脂肪性肝病。
Cells. 2021 Nov 25;10(12):3306. doi: 10.3390/cells10123306.
4
Macrophages in obesity and non-alcoholic fatty liver disease: Crosstalk with metabolism.肥胖与非酒精性脂肪性肝病中的巨噬细胞：与代谢的相互作用
JHEP Rep. 2019 Feb 23;1(1):30-43. doi: 10.1016/j.jhepr.2019.02.004. eCollection 2019 May.
5
Current and Emerging Approaches for Nonalcoholic Steatohepatitis Treatment.非酒精性脂肪性肝炎治疗的当前及新出现的方法
Gene Expr. 2019 Nov 4;19(3):175-185. doi: 10.3727/105221619X15536120524171. Epub 2019 Apr 2.
6
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.遗传肝脏特异性 AMPK 激活可预防饮食诱导的肥胖和非酒精性脂肪性肝病。
Cell Rep. 2019 Jan 2;26(1):192-208.e6. doi: 10.1016/j.celrep.2018.12.036.
7
Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.全球视角下的非酒精性脂肪性肝病和非酒精性脂肪性肝炎。
Hepatology. 2019 Jun;69(6):2672-2682. doi: 10.1002/hep.30251.
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Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids.肥胖、炎症、Toll 样受体 4 和脂肪酸。
Nutrients. 2018 Mar 30;10(4):432. doi: 10.3390/nu10040432.
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