Shrimal Preena, Jadeja Girirajsinh, Patel Sanjaykumar
Department of Chemical Engineering, S. V. National Institute of Technology, Surat, Gujarat 395007, India.
Department of Chemical Engineering, S. V. National Institute of Technology, Surat, Gujarat 395007, India.
Int J Pharm. 2022 May 25;620:121754. doi: 10.1016/j.ijpharm.2022.121754. Epub 2022 Apr 19.
A new method to prepare polymer encapsulated repaglinide nanoparticles through ultrasonic enhanced microchannel emulsification technique was explored. Using the concept of 3D printing, three different shaped micromixers (T-type, Y-type, and F-type) followed by a serpentine microchannel was fabricated using SS-316. Parametric study was performed on all three fabricated micromixers. The best results were obtained for the Y-microchannel in a microfluidic system alone, which showed a minimum particle size of 513.6 nm with 75.4% encapsulation efficiency (EE). In the selected microchannel, to further reduce the drug particle size and to increase% EE, convective mixing between immiscible fluids was enhanced by implementing ultrasound. Compared to the microfluidic system, particle size and EE were significantly improved in the ultrasonic microfluidic system. The experimental results revealed that the minimum particle size of 75.4 ± 1.3 nm with 82.9 ± 0.2% EE was achieved using an ultrasonic enhanced microfluidic system. The zeta potential of + 29.5 mV was obtained for emulsion prepared using the ultrasonic microfluidic system, whereas + 22 mV was prepared using a microfluidic system. Moreover, a backscattering measurement was performed to predict the stability of prepared emulsions. Integrating the ultrasound with a microfluidic system has proven beneficial for drug encapsulation.
探索了一种通过超声增强微通道乳化技术制备聚合物包裹瑞格列奈纳米颗粒的新方法。利用3D打印概念，使用SS-316制造了三种不同形状的微混合器（T型、Y型和F型），随后是一个蛇形微通道。对所有三种制造的微混合器进行了参数研究。仅在微流体系统中的Y型微通道获得了最佳结果，其显示最小粒径为513.6nm，包封率（EE）为75.4%。在选定的微通道中，为了进一步减小药物粒径并提高EE百分比，通过实施超声增强了不混溶流体之间的对流混合。与微流体系统相比，超声微流体系统中的粒径和EE有显著改善。实验结果表明，使用超声增强微流体系统可实现最小粒径为75.4±1.3nm，EE为82.9±0.2%。使用超声微流体系统制备的乳液的ζ电位为+29.5mV，而使用微流体系统制备的为+22mV。此外，进行了背散射测量以预测所制备乳液的稳定性。已证明将超声与微流体系统相结合有利于药物包封。
