Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Unit 1352, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
IsoTherapeutics Group, LLC, 1004 S. Velasco St, Angleton, TX, 77515, USA.
Appl Radiat Isot. 2022 Jul;185:110246. doi: 10.1016/j.apradiso.2022.110246. Epub 2022 Apr 14.
Thehuman internal dosimetry of the radionuclidic impurities of samarium-153 in a new bone-seeking radiopharmaceutical, Sm-1,4,7,10tetraazacyclododecanetetramethylenephosponic acid (Sm-DOTMP), has been estimated from preclinical data. The effective dose from the impurities in lower-specific-activity Sm is less than 17% of the effective dose from pure Sm-153. It has a background-equivalent radiation time for a dosage of 37 MBq/kg of less than one-half year.
从临床前数据估算了新型骨骼靶向放射性药物 Sm-153 中放射性核素杂质的人体内部剂量。低比活度 Sm 中的杂质所致有效剂量小于纯 Sm-153 的 17%。对于 37 MBq/kg 的剂量，其背景等效辐射时间不到半年。
