拟南芥组蛋白甲基化动态的结构与机制。
Structure and mechanism of histone methylation dynamics in Arabidopsis.
机构信息
Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
出版信息
Curr Opin Plant Biol. 2022 Jun;67:102211. doi: 10.1016/j.pbi.2022.102211. Epub 2022 Apr 19.
Histone methylation plays a central role in regulating chromatin state and gene expression in Arabidopsis and is involved in a variety of physiological and developmental processes. Dynamic regulation of histone methylation relies on both histone methyltransferase "writer" and histone demethylases "eraser" proteins. In this review, we focus on the four major histone methylation modifications in Arabidopsis H3, H3K4, H3K9, H3K27, and H3K36, and summarize current knowledge of the dynamic regulation of these modifications, with an emphasis on the biochemical and structural perspectives of histone methyltransferases and demethylases.
组蛋白甲基化在调控拟南芥染色质状态和基因表达方面起着核心作用，并参与多种生理和发育过程。组蛋白甲基化的动态调控依赖于组蛋白甲基转移酶“写入器”和组蛋白去甲基化酶“擦除器”蛋白。在这篇综述中，我们重点介绍了拟南芥 H3、H3K4、H3K9、H3K27 和 H3K36 这四种主要的组蛋白甲基化修饰，并总结了这些修饰的动态调控的最新知识，重点介绍了组蛋白甲基转移酶和去甲基化酶的生化和结构观点。
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