Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China.
Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China.
Biomed Pharmacother. 2022 Jun;150:112885. doi: 10.1016/j.biopha.2022.112885. Epub 2022 Apr 19.
Cancer persists as a worldwide disease that contributes to high morbidity and mortality rates. As a class of non-coding RNA, microRNAs (miRNAs) are one kind of important regulators in cancer and frequently implicated in tumor development and progression. Emerging experiments have suggested that miRNA-195-5p (miR-195-5p) can regulate neoplastic processes in many pathways. For instance, miR-195-5p can not only regulate proliferation, migration and invasion of tumor cells but also promote tumor cell apoptosis. Furthermore, low expression of miR-195-5p could induce drug resistance. Our review focuses on the expression of miR-195-5p in various tumors and elucidates the related mechanisms of which miR-195-5p participates in tumor biology, as well as summarizes the roles of miR-195-5p in tumor progression. We believe that miR-195-5p might have potential utility as a novel diagnostic biomarker and therapeutic target for cancer.
癌症仍然是一种全球性疾病，导致高发病率和死亡率。作为一类非编码 RNA，microRNAs（miRNAs）是癌症中的一种重要调节因子，经常涉及肿瘤的发生和发展。新兴的实验表明，miRNA-195-5p（miR-195-5p）可以在许多途径中调节肿瘤的发生过程。例如，miR-195-5p 不仅可以调节肿瘤细胞的增殖、迁移和侵袭，还可以促进肿瘤细胞凋亡。此外，miR-195-5p 的低表达可诱导耐药性。我们的综述重点关注 miR-195-5p 在各种肿瘤中的表达，并阐明其参与肿瘤生物学的相关机制，以及总结 miR-195-5p 在肿瘤进展中的作用。我们相信 miR-195-5p 可能具有作为癌症新型诊断生物标志物和治疗靶点的潜力。
