Henning Thorsten, Kochlik Bastian, Kusch Paula, Strauss Matthias, Jurić Viktorija, Pignitter Marc, Marusch Frank, Grune Tilman, Weber Daniela
Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.
Food4Future (F4F), c/o Leibniz Institute of Vegetable and Ornamental Crops (IGZ), 14979 Grossbeeren, Germany.
Antioxidants (Basel). 2022 Apr 13;11(4):774. doi: 10.3390/antiox11040774.
Obesity has been linked to lower concentrations of fat-soluble micronutrients and higher concentrations of oxidative stress markers as well as an altered metabolism of branched chain amino acids and phospholipids. In the context of morbid obesity, the aim of this study was to investigate whether and to which extent plasma status of micronutrients, amino acids, phospholipids and oxidative stress differs between morbidly obese (n = 23) and non-obese patients (n = 13). In addition to plasma, malondialdehyde, retinol, cholesterol and triglycerides were assessed in visceral and subcutaneous adipose tissue in both groups. Plasma γ-tocopherol was significantly lower (p < 0.011) in the obese group while other fat-soluble micronutrients showed no statistically significant differences between both groups. Branched-chain amino acids (all p < 0.008) and lysine (p < 0.006) were significantly higher in morbidly obese patients compared to the control group. Malondialdehyde concentrations in both visceral (p < 0.016) and subcutaneous (p < 0.002) adipose tissue were significantly higher in the morbidly obese group while plasma markers of oxidative stress showed no significant differences between both groups. Significantly lower plasma concentrations of phosphatidylcholine, phosphatidylethanolamine, lyso-phosphatidylethanolamine (all p < 0.05) and their corresponding ether-linked analogs were observed, which were all reduced in obese participants compared to the control group. Pre-operative assessment of micronutrients in patients undergoing bariatric surgery is recommended for early identification of patients who might be at higher risk to develop a severe micronutrient deficiency post-surgery. Assessment of plasma BCAAs and phospholipids in obese patients might help to differentiate between metabolic healthy patients and those with metabolic disorders.
肥胖与脂溶性微量营养素浓度降低、氧化应激标志物浓度升高以及支链氨基酸和磷脂代谢改变有关。在病态肥胖的背景下，本研究的目的是调查病态肥胖患者（n = 23）和非肥胖患者（n = 13）之间微量营养素、氨基酸、磷脂的血浆状态以及氧化应激在何种程度上存在差异。除血浆外，还评估了两组内脏和皮下脂肪组织中的丙二醛、视黄醇、胆固醇和甘油三酯。肥胖组血浆γ-生育酚显著降低（p < 0.011），而其他脂溶性微量营养素在两组之间无统计学显著差异。与对照组相比，病态肥胖患者的支链氨基酸（均p < 0.008）和赖氨酸（p < 0.006）显著更高。病态肥胖组内脏（p < 0.016）和皮下（p < 0.002）脂肪组织中的丙二醛浓度均显著更高，而氧化应激的血浆标志物在两组之间无显著差异。观察到磷脂酰胆碱、磷脂酰乙醇胺、溶血磷脂酰乙醇胺（均p < 0.05）及其相应的醚键连接类似物的血浆浓度显著降低，与对照组相比，肥胖参与者的这些物质均有所减少。建议对接受减肥手术的患者进行术前微量营养素评估，以便早期识别术后可能有更高严重微量营养素缺乏风险的患者。评估肥胖患者的血浆支链氨基酸和磷脂可能有助于区分代谢健康的患者和有代谢紊乱的患者。
