Pradel-Mora Jessica Juliana, Marín Gerardo, Castillo-Rangel Carlos, Hernández-Contreras Karla Aketzalli, Vichi-Ramírez Micheel Merari, Zarate-Calderon Cristofer, Herran Motta Fanny Stella
From the Plastic and Reconstructive Surgery, "UMAE Hospital de Especialidades Dr. Bernardo Sepúlveda Gutiérrez, Centro Médico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico.
Neural Dynamics and Modulation Lab, Cleveland Clinic, Cleveland, Ohio.
Plast Reconstr Surg Glob Open. 2024 Mar 21;12(3):e5646. doi: 10.1097/GOX.0000000000005646. eCollection 2024 Mar.
The present study investigates the impact of oxidative stress after bariatric surgery in patients with obesity. This field of study has gained great interest in recent years due to the role that oxidative stress plays in metabolic diseases. Obesity, by itself, can generate an increase in reactive oxygen and nitrogen species, intensifying cellular damage and promoting the progression of adverse metabolic conditions. In this context, bariatric surgery emerges as a candidate capable of modifying oxidative stress biomarkers, facilitating the patient's metabolic recovery.
A systematic review was carried out, identifying 30 studies found in databases such as PubMed, Scopus, Web of Science, and Google Scholar. It looked at the link between oxidative stress and recovery after bariatric surgery in patients. The selection of studies was based on the measurement of oxidative stress biomarkers before and after surgical intervention.
The results reveal a significant decrease in oxidative stress biomarkers after bariatric surgery. However, a notable variability in antioxidant activity is observed between different patients, as well as a significant influence of comorbidities.
Bariatric surgery is postulated as an effective intervention in reducing oxidative stress in patients with obesity, enhancing antioxidant activity and improving patient recovery. This finding highlights the importance of considering oxidative stress management as an integral part of postoperative care, suggesting the need to implement complementary treatment strategies to optimize health outcomes.
本研究调查了肥胖患者接受减肥手术后氧化应激的影响。近年来，由于氧化应激在代谢性疾病中所起的作用，这一研究领域引起了极大的关注。肥胖本身会导致活性氧和氮物质增加，加剧细胞损伤并促进不良代谢状况的发展。在此背景下，减肥手术成为一种能够改变氧化应激生物标志物、促进患者代谢恢复的手段。
进行了一项系统综述，在PubMed、Scopus、科学网和谷歌学术等数据库中检索到30项研究。研究观察了肥胖患者减肥手术后氧化应激与恢复之间的联系。研究的选择基于手术干预前后氧化应激生物标志物的测量。
结果显示减肥手术后氧化应激生物标志物显著降低。然而，不同患者之间抗氧化活性存在显著差异，合并症也有显著影响。
减肥手术被认为是减轻肥胖患者氧化应激的有效干预措施，可增强抗氧化活性并改善患者恢复情况。这一发现凸显了将氧化应激管理作为术后护理不可或缺的一部分的重要性，表明需要实施补充治疗策略以优化健康结果。
