Maeda Keiko, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Ishikawa Eri, Oishi Akina, Ikegami Shuji, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki
Department of Endoscopy, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Biomedicines. 2022 Apr 9;10(4):872. doi: 10.3390/biomedicines10040872.
The therapeutic goal in ulcerative colitis is mucosal healing, which requires improved non-invasive biomarkers to evaluate disease activity. Gelsolin is associated with several autoimmune diseases, and here, we aimed to analyze its usefulness as a serological biomarker for clinical and endoscopic activities in ulcerative colitis. Patients with ulcerative colitis ( = 138) who had undergone blood tests and colonoscopy were included. Serum gelsolin was measured using enzyme-linked immunosorbent assay, and correlation between the gelsolin level and clinical and endoscopic activities was examined. The serum gelsolin level in patients with ulcerative colitis was significantly lower than that in healthy subjects, and it decreased in proportion to increasing Mayo score and Mayo endoscopic subscore. The area under the curve for correlation between clinical and endoscopic remission and serum gelsolin level was higher than that for C-reactive protein. Furthermore, in C-reactive protein-negative patients, the serum gelsolin level was lower in the active phase than in remission. Our findings indicate that the serum gelsolin level correlates with clinical and endoscopic activities in ulcerative colitis, has a higher sensitivity and specificity than C-reactive protein, and can detect mucosal healing, suggesting that gelsolin can be used as a biomarker for ulcerative colitis.
溃疡性结肠炎的治疗目标是黏膜愈合，这需要改进非侵入性生物标志物来评估疾病活动度。凝溶胶蛋白与多种自身免疫性疾病相关，在此，我们旨在分析其作为溃疡性结肠炎临床和内镜活动度血清生物标志物的效用。纳入了138例接受过血液检测和结肠镜检查的溃疡性结肠炎患者。采用酶联免疫吸附测定法检测血清凝溶胶蛋白，并检查凝溶胶蛋白水平与临床和内镜活动度之间的相关性。溃疡性结肠炎患者的血清凝溶胶蛋白水平显著低于健康受试者，且其水平随梅奥评分和梅奥内镜亚评分的增加而降低。临床和内镜缓解与血清凝溶胶蛋白水平之间相关性的曲线下面积高于C反应蛋白。此外，在C反应蛋白阴性的患者中，活动期血清凝溶胶蛋白水平低于缓解期。我们的研究结果表明，血清凝溶胶蛋白水平与溃疡性结肠炎的临床和内镜活动度相关，比C反应蛋白具有更高的敏感性和特异性，并且能够检测黏膜愈合，提示凝溶胶蛋白可作为溃疡性结肠炎的生物标志物。
