Department of Functional and Clinical Anatomy,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Germany.
Medical Specialist for Orthopedics as Well as Orthopedic and Rheumatologic Chiropractic,Physical Therapy and Sports Medicine,Rottach-Egern,Germany.
Expert Rev Mol Med. 2019 Jan 30;20:e7. doi: 10.1017/erm.2018.7.
Gelsolin (GSN), one of the most abundant actin-binding proteins, is involved in cell motility, shape and metabolism. As a member of the GSN superfamily, GSN is a highly structured protein in eukaryotic cells that can be regulated by calcium concentration, intracellular pH, temperature and phosphatidylinositol-4,5-bisphosphate. GSN plays an important role in cellular mechanisms as well as in different cellular interactions. Because of its participation in immunologic processes and its interaction with different cells of the immune system, GSN is a potential candidate for various therapeutic applications. In this review, we summarise the structure of GSN as well as its regulating and functional roles, focusing on distinct diseases such as Alzheimer's disease, rheumatoid arthritis and cancer. A short overview of GSN as a therapeutic target in today's medicine is also provided.
凝胶蛋白（GSN）是含量最丰富的肌动蛋白结合蛋白之一，参与细胞运动、形态和代谢。作为 GSN 超家族的一员，GSN 是真核细胞中高度结构化的蛋白质，可通过钙离子浓度、细胞内 pH 值、温度和磷脂酰肌醇-4,5-二磷酸调节。GSN 在细胞机制以及不同的细胞相互作用中都起着重要作用。由于其参与免疫过程以及与免疫系统的不同细胞相互作用，GSN 是各种治疗应用的潜在候选物。在这篇综述中，我们总结了 GSN 的结构及其调节和功能作用，重点介绍了阿尔茨海默病、类风湿关节炎和癌症等不同疾病。还简要概述了 GSN 作为当今医学治疗靶点的应用。
