Strzelak Agnieszka, Komorowska-Piotrowska Anna, Krenke Katarzyna, Zagórska Wioletta, Bartosiewicz Witold, Feleszko Wojciech, Kulus Marek
Department of Pediatric Pulmonology and Allergy, Medical University of Warsaw, 02-091 Warsaw, Poland.
Diagnostics (Basel). 2022 Mar 29;12(4):840. doi: 10.3390/diagnostics12040840.
IP-10 has been proposed as a new diagnostic biomarker for infection (MTBI). However, data on IP-10 concentration in bronchoalveolar lavage fluid (BALF) for pediatric tuberculosis are lacking.
To determine IP-10 levels in unstimulated BALF and plasma in children with and without MTBI.
IP-10 concentrations in BALF and plasma were measured in children hospitalized with suspected tuberculosis or other respiratory disease and scheduled for bronchoscopy. Thirty-five children were enrolled: 13 with suspected tuberculosis and 22 controls. The association between IP-10 and age was examined.
The IP-10 expression was increased in BALF compared to plasma ( = 0.008). We noticed higher BALF IP-10 levels in children with asthma, interstitial lung disease, and lung anomaly than in children with MTBI and other respiratory tract infections, but the differences were statistically insignificant. There was a moderate correlation between plasma and BALF IP-10 concentrations (r = 0.46, = 0.018). No correlation between IP-10 level and age was detected.
IP-10 is detectable in unstimulated BALF in children with respiratory diseases, reaches higher concentrations in unstimulated BALF vs plasma, and does not correlate with age. However, it could not discriminate MTBI from other respiratory diseases.
IP-10已被提议作为感染（轻度创伤性脑损伤）的一种新的诊断生物标志物。然而，关于儿童结核病支气管肺泡灌洗液（BALF）中IP-10浓度的数据尚缺。
确定患有和未患有轻度创伤性脑损伤的儿童未受刺激的BALF和血浆中的IP-10水平。
对因疑似结核病或其他呼吸道疾病住院并计划进行支气管镜检查的儿童，检测其BALF和血浆中的IP-10浓度。共纳入35名儿童：13名疑似结核病患儿和22名对照。研究了IP-10与年龄之间的关联。
与血浆相比，BALF中的IP-10表达增加（P = 0.008）。我们注意到，哮喘、间质性肺疾病和肺发育异常患儿的BALF中IP-10水平高于轻度创伤性脑损伤和其他呼吸道感染患儿，但差异无统计学意义。血浆和BALF中IP-10浓度之间存在中度相关性（r = 0.46，P = 0.018）。未检测到IP-10水平与年龄之间的相关性。
患有呼吸道疾病的儿童未受刺激的BALF中可检测到IP-10，未受刺激的BALF中IP-10浓度高于血浆，且与年龄无关。然而，它无法将轻度创伤性脑损伤与其他呼吸道疾病区分开来。
