Wong Yin Ping, Kabincong Connie, Jabar Mohd Faisal, Tan Geok Chin
Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Prince Court Medical Centre, Jalan Kia Peng, Kuala Lumpur 50450, Malaysia.
Diagnostics (Basel). 2022 Apr 12;12(4):966. doi: 10.3390/diagnostics12040966.
Mucosal prolapse syndrome is also known as solitary rectal ulcer syndrome. It may either presents as an ulcer or polyp, which could mimic other pathological lesions such as juvenile polyp, hyperplastic polyp, adenomatous polyp, polyp related inflammatory bowel disease and adenocarcinoma. It can pose as a diagnostic challenge to both the surgeons and pathologists due to the overlapping gross and histological features. The characteristic histological features of mucosal prolapse syndrome are fibromuscular obliteration of lamina propria and splayed hypertrophic muscularis mucosae. It can occur in a wide range of ages, including children and teenagers. Rectal bleeding is one of the common presenting symptoms. Here, we described two cases of mucosal prolapse syndrome presented as rectal polyposis and provide a discussion on its histological differential diagnosis.
黏膜脱垂综合征也被称为孤立性直肠溃疡综合征。它可表现为溃疡或息肉，可能会与其他病理病变相似，如幼年性息肉、增生性息肉、腺瘤性息肉、息肉相关的炎症性肠病和腺癌。由于大体和组织学特征重叠，这给外科医生和病理学家都带来了诊断挑战。黏膜脱垂综合征的特征性组织学特征是固有层纤维肌性闭塞和黏膜肌层肥厚展开。它可发生于广泛的年龄范围，包括儿童和青少年。直肠出血是常见的临床表现之一。在此，我们描述了两例表现为直肠息肉病的黏膜脱垂综合征病例，并对其组织学鉴别诊断进行了讨论。
