Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Biomolecules. 2022 Mar 23;12(4):488. doi: 10.3390/biom12040488.
The sarcoplasmic reticulum of skeletal muscle cells is a highly ordered structure consisting of an intricate network of tubules and cisternae specialized for regulating Ca homeostasis in the context of muscle contraction. The sarcoplasmic reticulum contains several proteins, some of which support Ca storage and release, while others regulate the formation and maintenance of this highly convoluted organelle and mediate the interaction with other components of the muscle fiber. In this review, some of the main issues concerning the biology of the sarcoplasmic reticulum will be described and discussed; particular attention will be addressed to the structure and function of the two domains of the sarcoplasmic reticulum supporting the excitation-contraction coupling and Ca-uptake mechanisms.
骨骼肌细胞的肌浆网是一种高度有序的结构，由专门用于调节肌肉收缩时钙稳态的复杂小管和小泡网络组成。肌浆网包含几种蛋白质，其中一些支持钙的储存和释放，而另一些则调节这种高度卷曲细胞器的形成和维持，并介导与肌肉纤维其他成分的相互作用。在这篇综述中，将描述和讨论肌浆网生物学的一些主要问题；特别关注支持兴奋-收缩偶联和钙摄取机制的肌浆网两个区域的结构和功能。
