Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Wexner Medical Center, The Ohio State University, Columbus, OH, United States of America.
Biomedical & Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, United States of America.
J Mol Cell Cardiol. 2021 Jul;156:105-113. doi: 10.1016/j.yjmcc.2021.04.002. Epub 2021 Apr 17.
Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to malignant cardiac arrhythmias. Both defective mitochondrial function and abnormal intracellular Ca homeostasis have been established as the key contributing factors in the pathophysiology and arrhythmogenesis in these conditions. This article reviews current advances in understanding of bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca release and mitochondrial function, and how defects in crosstalk between these two organelles increase arrhythmic risk in cardiac disease.
由于室性心律失常导致的心脏性猝死仍然是全球范围内主要的致死原因。心力衰竭、糖尿病性心肌病、与年龄相关的老年人心力衰竭和遗传性疾病与恶性心律失常的易发性增强相关。线粒体功能缺陷和细胞内 Ca2+ 稳态异常已被确立为这些情况下病理生理学和心律失常发生的关键因素。本文综述了目前对兰尼碱受体介导的肌浆网 Ca2+ 释放和线粒体功能双向控制的理解进展，以及这两个细胞器之间的通讯缺陷如何增加心脏疾病中的心律失常风险。
