Sreepada T K, Gupta S K, Butt K M, Kountz S L, Friedman E A
Arch Intern Med. 1978 Aug;138(8):1236-41. doi: 10.1001/archinte.138.8.1236.
The relationship of renal transplantation to new onset or persistence of previously established hypertension was analyzed in 164 transplant recipients in whom the renal allograft functioned for six months or longer. Of the 164, thirty-seven (23%) had normal blood pressure and 127 (77%) were hypertensive prior to transplantation. Following transplantation 83 patients (51%) were normotensive; high blood pressure was found in 81 (49%). Posttransplant hypertension could not be correlated with the recipient's original renal disease, age, sex, renal donor source, donor age, or maintenance dose of prednisone. More normotensive paients had undergone prior binephrectomy when compared with the hypertensive group (P less than .05). Mean serum creatinine levels was higher (2.0 mg/dl) in hypertensives than in normotensives (1.54 mg/dl) (P greater than .05). Selective renal veins' renin measurements in patients with severe hypertension were not helpful in predicting the beneficial effects of either bilateral nephrectomy or surgical correction of transplant renal artery stenosis.
对164例移植肾发挥功能6个月或更长时间的肾移植受者，分析了肾移植与新发高血压或既往已存在高血压持续状态之间的关系。164例患者中，37例（23%）血压正常，127例（77%）移植前有高血压。移植后，83例患者（51%）血压正常；81例（49%）有高血压。移植后高血压与受者原来的肾脏疾病、年龄、性别、肾供体来源、供体年龄或泼尼松维持剂量无关。与高血压组相比，更多血压正常的患者曾接受过双侧肾切除术（P<0.05）。高血压患者的平均血清肌酐水平（2.0mg/dl）高于血压正常者（1.54mg/dl）（P>0.05）。对重度高血压患者进行选择性肾静脉肾素测定，无助于预测双侧肾切除术或移植肾动脉狭窄手术矫正的有益效果。
