儿童长新冠:从发病机制到该综合征的生物学可能根源。
Long COVID-19 in Children: From the Pathogenesis to the Biologically Plausible Roots of the Syndrome.
机构信息
Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, 37126 Verona, Italy.
Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, 56126 Pisa, Italy.
出版信息
Biomolecules. 2022 Apr 8;12(4):556. doi: 10.3390/biom12040556.
Long Coronavirus disease-19 (COVID-19) refers to the persistence of symptoms related to the infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). This condition is described as persistent and can manifest in various combinations of signs and symptoms, such as fatigue, headache, dyspnea, depression, cognitive impairment, and altered perception of smells and tastes. Long COVID-19 may be due to long-term damage to different organs-such as lung, brain, kidney, and heart-caused by persisting viral-induced inflammation, immune dysregulation, autoimmunity, diffuse endothelial damage, and micro thrombosis. In this review, we discuss the potential and biologically plausible role of some vitamins, essential elements, and functional foods based on the hypothesis that an individual's dietary status may play an important adjunctive role in protective immunity against COVID-19 and possibly against its long-term consequences.
长期冠状病毒病-19(COVID-19)是指与严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)感染相关的症状持续存在。这种情况被描述为持续性的,并可能以疲劳、头痛、呼吸困难、抑郁、认知障碍和嗅觉、味觉改变等各种症状和体征的组合表现出来。长 COVID-19 可能是由于持续的病毒诱导炎症、免疫失调、自身免疫、弥漫性内皮损伤和微血栓形成导致不同器官(如肺、脑、肾和心脏)的长期损伤所致。在这篇综述中,我们根据这样一种假设讨论了一些维生素、必需元素和功能性食品的潜在和合理的生物学作用,即个体的饮食状况可能在对抗 COVID-19 及其长期后果的保护性免疫中发挥重要的辅助作用。