Department of Pediatric Gastroenterology Hepatology and Nutrition, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Department of Microbiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Acta Paediatr. 2022 Feb;111(2):383-388. doi: 10.1111/apa.16173. Epub 2021 Nov 11.
We aimed to analyse the influence of the COVID-19 pandemic on the frequency and clinical presentation of celiac disease.
The study included the patients with celiac disease since January 2008. They were divided into 2 groups (diagnosed in pre-pandemic [January 2008 and February 2020] [n = 148] and in pandemic period [March 2020 and June 2021] [n = 47]). Clinical and histological findings were compared between groups. Additionally, data about severe acute respiratory syndrome coronavirus 2 infection were obtained in subgroup patients (n = 22) with celiac disease diagnosed during pandemic period.
The number of patients per year (12.1-37.6) and the percentage of patients who were diagnosed with celiac disease/total endoscopy were increased during the pandemic period (2.2% vs. 10%, p < 0.00001). The association of celiac disease with type 1 diabetes mellitus was significantly high in pandemic period (4% vs. 17%, p = 0.002). Frequency of moderate-severe mucosal lesions was low in pandemic period (42.4% vs. 81.7%, p = 0.0001). Clinical and laboratory markers for the past severe acute respiratory syndrome coronavirus 2 infection were found in 36.3% of patients diagnosed during the pandemic period.
It seems that the frequency of celiac disease and its association with type 1 diabetes mellitus is increased during the COVID-19 pandemic in children.
分析 COVID-19 大流行对乳糜泻发病频率和临床表现的影响。
本研究纳入了自 2008 年 1 月以来的乳糜泻患者。将其分为 2 组（大流行前[2008 年 1 月至 2020 年 2 月]诊断的患者[n=148]和大流行期间[2020 年 3 月至 2021 年 6 月]诊断的患者[n=47]）。比较两组的临床和组织学发现。此外，在大流行期间诊断为乳糜泻的亚组患者（n=22）中获得了关于严重急性呼吸综合征冠状病毒 2 感染的数据。
大流行期间每年的患者人数（12.1-37.6）和诊断为乳糜泻的患者百分比/总内镜检查的百分比（2.2%比 10%，p<0.00001）增加。大流行期间乳糜泻与 1 型糖尿病的相关性显著升高（4%比 17%，p=0.002）。大流行期间中度-重度黏膜病变的频率较低（42.4%比 81.7%，p=0.0001）。在大流行期间诊断的患者中有 36.3%发现过去严重急性呼吸综合征冠状病毒 2 感染的临床和实验室标志物。
在儿童 COVID-19 大流行期间，乳糜泻的发病率及其与 1 型糖尿病的相关性似乎增加。
